https://scholars.lib.ntu.edu.tw/handle/123456789/557562
標題: | Evaluation of third-generation hepatitis C antibody assay in chronic hepatitis C and chronic non-B, non-C hepatitis | 作者: | JIA-HORNG KAO PEI-MING YANG Lai M.-Y. PEI-JER CHEN Wang T.-H. DING-SHINN CHEN |
公開日期: | 1995 | 出版社: | Mary Ann Liebert Inc. | 卷: | 8 | 期: | 3 | 起(迄)頁: | 135-139 | 來源出版物: | Viral Immunology | 摘要: | Second-generation hepatitis C virus (HCV) antibody assays are more sensitive and specific than first-generation assays in the detection of HCV infection; such tests are widely used. However, there are still HCV-infected patients who test seronegative for anti-HCV even by second-generation assays. In this study we evaluated the performance of the new third-generation HCV assay (HCV 3.0) in 230 individuals with different second-generation anti-HCV (HCV 2.0) and HCV RNA patterns. Our results showed the followings: only one healthy adult had a discrepant result in 200 subjects negative (group I) or positive (group II) for HCV 2.0 and HCV RNA; 7 of 13 (54%) HCV 2.0-negative but HCV RNA-positive patients (group III) were HCV 3.0-positive; two of 17 (12%) so-called chronic non-B, non-C hepatitis patients (group IV) were positive for HCV 3.0. We conclude that third-generation anti-HCV assays are more sensitive and specific than second-generation assays in the detection of chronic HCV infection; however false-positive results may be observed among low-risk healthy persons. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0029554713&doi=10.1089%2fvim.1995.8.135&partnerID=40&md5=105692da0bd92b4da6334fa0cef60f9c https://scholars.lib.ntu.edu.tw/handle/123456789/557562 |
ISSN: | 0882-8245 | DOI: | 10.1089/vim.1995.8.135 | SDG/關鍵字: | hepatitis C antibody; adult; article; controlled study; female; hepatitis; hepatitis C; human; immunoassay; major clinical study; male; serodiagnosis; virus detection; Hepatitis C virus |
顯示於: | 醫學系 |
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