https://scholars.lib.ntu.edu.tw/handle/123456789/557571
標題: | Mixed infections of hepatitis c virus as a factor in acute exacerbations of chronic type c hepatitis | 作者: | JIA-HORNG KAO PEI-JER CHEN Lai M.-Y. PEI-MING YANG JIN-CHUAN SHEU Wang T.-H. DING-SHINN CHEN |
公開日期: | 1994 | 卷: | 170 | 期: | 5 | 起(迄)頁: | 1128-1133 | 來源出版物: | Journal of Infectious Diseases | 摘要: | Twenty patients with chronic hepatitis C virus (HCV) infection and acute exacerbations (group A) were studied by polymerase chain reaction with genotype-specific primers to explore the role of mixed infections of HCV in acute exacerbations of chronic type C hepatitis. Another 26 patients who did not have acute exacerbation were matched controls (group B). Eleven (55%) of the group A patients had heterologous HCV, and their mean age was significantly younger than that of the 9 without heterologous infection (55 vs. 67 years, P <.05). In contrast, only 2 group B patients (7.7%) had heterologous HCV infection. In 10 of 13 patients with heterologous HCV infection, type III/2a virus emerged on type II/1b HCV, and viral interference was observed in half of them. The results support that mixed infections of HCV may be important in acute exacerbations of chronic type C hepatitis. ? 1994 by The University of Chicago. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0028034973&doi=10.1093%2finfdis%2f170.5.1128&partnerID=40&md5=4921c4136242d405e1a2253d264e2949 https://scholars.lib.ntu.edu.tw/handle/123456789/557571 |
ISSN: | 0022-1899 | DOI: | 10.1093/infdis/170.5.1128 | SDG/關鍵字: | adult; aged; article; chronic disease; clinical article; female; genetic heterogeneity; genotype; hepatitis c virus; human; liver biopsy; male; mixed infection; molecular cloning; polymerase chain reaction; priority journal; superinfection; virus genome; virus infection; virus transmission; Acute Disease; Adult; Aged; Aged, 80 and over; Chronic Disease; Female; Genotype; Hepacivirus; Hepatitis C; Human; Male; Middle Age; Polymerase Chain Reaction; Support, Non-U.S. Gov't |
顯示於: | 醫學系 |
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