https://scholars.lib.ntu.edu.tw/handle/123456789/558421
Title: | AST-120 Improves Cardiac Dysfunction in Acute Kidney Injury Mice via Suppression of Apoptosis and Proinflammatory NF-κB/ICAM-1 Signaling | Authors: | Shen, Wen-Ching YU-HSIANG CHOU Shi, Li-Shian Chen, Zhi-Wei Tu, Hai-Jian Lin, Xin-Yi Wang, Guei-Jane |
Keywords: | AST-120; NF-κB; acute kidney injury; apoptosis; cardiac dysfunction; inflammation | Issue Date: | 2021 | Journal Volume: | 14 | Source: | Journal of inflammation research | Abstract: | Acute kidney injury (AKI) is a devastating disorder associated with considerably high morbidity and mortality. Reports have shown that AST-120, an oral charcoal adsorbent, can reduce oxidative stress by lowering serum indoxyl sulfate levels. The effects of AST-120 and indoxyl sulfate on kidney injury and cardiac dysfunction were investigated in vivo and in vitro. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/558421 | ISSN: | 1178-7031 | DOI: | 10.2147/JIR.S283378 | SDG/Keyword: | ast 120; brain natriuretic peptide; indican; intercellular adhesion molecule 1; interleukin 1beta; nitrogen; urea; acute kidney failure; animal experiment; animal model; animal tissue; apoptosis; Article; blood level; blood sampling; cardiac muscle cell; clinical article; clinical effectiveness; cohort analysis; controlled study; creatinine blood level; down regulation; echocardiography; enzyme linked immunosorbent assay; heart failure; heart left ventricle ejection fraction; heart output; histopathology; human; human cell; in vitro study; in vivo study; inflammation; kidney function; liquid chromatography; mouse; NF kappaB ICAM 1 signaling; nonhuman; oxidative stress; reperfusion injury; signal transduction; treatment duration; TUNEL assay; umbilical vein endothelial cell; urea nitrogen blood level; Western blotting |
Appears in Collections: | 醫學系 |
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