Applicability of minimally invasive surgery for clinically T4 colorectal cancer
Journal
Scientific Reports
Journal Volume
10
Journal Issue
1
Date Issued
2020
Author(s)
Abstract
The role of minimally invasive surgery (MIS) to treat clinically T4 (cT4) colorectal cancer (CRC) remains uncertain and deserves further investigation. A retrospective cohort study was conducted between September 2006 and March 2019 recruiting patients diagnosed as cT4 CRC and undergoing MIS at a university hospital and its branch. Patients’ demography, clinicopathology, surgical and oncological outcomes, and radicality were analyzed. A total of 128 patients were recruited with an average follow-up period of 33.8?months. The median time to soft diet was 6?days, and the median postoperative hospitalization periods was 11?days. The conversion and complication (Clavien–Dindo classification ? II) rates were 7.8% and 27.3%, respectively. The 30-day mortality was 0.78%. R0 resection rate was 92.2% for cT4M0 and 88.6% for pT4M0 patients. For cT4 CRC patients, the disease-free survival and 3-year overall survival were 86.1% and 86.8% for stage II, 54.1% and 57.9% for stage III, and 10.8% and 17.8% for stage IV. With acceptable conversion, complication and mortality rate, MIS may achieve satisfactory R0 resection rate and thus lead to good oncological outcomes for selected patients with cT4 CRC. ? 2020, The Author(s).
SDGs
Other Subjects
adult; aged; bladder; cancer staging; colon; colorectal tumor; female; human; laparoscopy; male; middle aged; minimally invasive surgery; mortality; pathology; postoperative complication; procedures; retrospective study; small intestine; survival analysis; uterine adnexa; uterus; very elderly; Adnexa Uteri; Adult; Aged; Aged, 80 and over; Colon; Colorectal Neoplasms; Female; Humans; Intestine, Small; Laparoscopy; Male; Middle Aged; Minimally Invasive Surgical Procedures; Neoplasm Staging; Postoperative Complications; Retrospective Studies; Survival Analysis; Urinary Bladder; Uterus
Publisher
Nature Research
Type
journal article