Circulating intercellular adhesion molecule-1 and lymphocyte subsets involved in immune response of breast cancer.
Journal
Zhonghua Minguo wei sheng wu ji mian yi xue za zhi = Chinese journal of microbiology and immunology
Journal Volume
26
Journal Issue
1
Pages
1-5
Date Issued
1993
Author(s)
Abstract
To understand the immune responses of patients with breast cancer, circulating intercellular adhesion molecules-1 (ICAM-1) and lymphocyte subsets were measured in patients with breast cancer and in healthy persons. There were 10 patients of with metastasis, 11 patients breast cancer without metastasis and 9 age-and-sex matched healthy persons. Their serum samples were counted for circulating ICAM-1 levels, and blood cells were calculated for lymphocyte subpopulation including CD3, CD4, CD8 and CD19 by using flow cytometry. Higher levels of circulating ICAM-1 were noted in patients with breast cancer and metastasis than those without metastasis (p < 0.01). Lower percentage of CD8 lymphocyte subset were found ih patients with breast cancer and metastasis than those without metastasis (p < 0.05). Shedding of ICAM-1 antigens from the tumor may block the attachment of cytotoxic T cells, and decreased numbers of cytotoxic T cells may be unable to inhibit the spread of cancer cells. Immune responses of patients with breast cancer may be different between metastatic status and limited status. Further investigations should correlate the results of tissue stains of breast cancer with ICAM-1 and lymphocyte markers with those from peripheral blood.
SDGs
Other Subjects
cell adhesion molecule; intercellular adhesion molecule 1; adult; aged; article; blood; breast tumor; female; human; immunology; middle aged; T lymphocyte subpopulation; Adult; Aged; Breast Neoplasms; Cell Adhesion Molecules; Female; Humans; Intercellular Adhesion Molecule-1; Middle Aged; T-Lymphocyte Subsets
Type
journal article