https://scholars.lib.ntu.edu.tw/handle/123456789/558795
標題: | Incidence, risk factor, and prognosis of end-stage renal disease after heart transplantation in Chinese recipients | 作者: | JENG-WEI CHEN Lin, Cheng-Hsin |
公開日期: | 2014 | 卷: | 113 | 期: | 1 | 起(迄)頁: | 11-16 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background/Purpose: End-stage renal disease (ESRD) is an important complication arising after heart transplantation. At least 3-10% of recipients reach ESRD within 10 years after transplant. The incidence of ESRD in Chinese recipients has not been reported. Here we sought to assess the incidence, prognosis, and risk factors for ESRD in Chinese recipients. Methods: We conducted a retrospective analysis of 248 heart recipients who survived >1 year from 1998 through 2007. ESRD was defined as the requirement of maintenance dialysis. Results: Renal dysfunction was present in 20 patients (8%) prior to transplant. With a follow-up duration of 5.8±3.9 years, 30 patients developed ESRD. The cumulative incidence of ESRD after heart transplantation was 2.1%±0.9%, 6.5%±1.8%, 16.8%±3.3%, and 36.5%±9.5% at 2, 5, 10, and 15 years after transplant, respectively. Median onset of ESRD was 6.9 years after transplant. Actuarial survival after dialysis was 74.8%±8.3%, 66.6%±9.2%, and 43.6%±12.6% at 1, 2, and 5 years, respectively. Independent risk factors for ESRD included pretransplant serum creatinine (hazard ratio, 1.84; p=0.001), presence of diabetes prior to transplant (hazard ratio, 2.51; p=0.017), and old age at transplant (hazard ratio, 1.05; p=0.008). Conclusion: There was a high incidence of ESRD in Chinese heart recipients. Patients with ESRD had poor prognosis after dialysis. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84892493552&doi=10.1016%2fj.jfma.2012.04.012&partnerID=40&md5=9b5acdc8f9574fe42124d9cc940dc980 https://scholars.lib.ntu.edu.tw/handle/123456789/558795 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2012.04.012 | SDG/關鍵字: | creatinine; adult; aged; article; child; Chinese; creatinine blood level; diabetes mellitus; dialysis; end stage renal disease; female; follow up; glomerulus filtration rate; graft recipient; heart transplantation; human; kidney dysfunction; major clinical study; male; medical record review; preoperative period; prognosis; risk factor; senescence; survival; urea nitrogen blood level; very elderly; Asian continental ancestry group; heart transplantation; Kidney Failure, Chronic; mortality; postoperative complication; prognosis; retrospective study; Taiwan; Asian Continental Ancestry Group; Heart Transplantation; Humans; Kidney Failure, Chronic; Postoperative Complications; Prognosis; Retrospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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