Pregnancy Incidence in Female Nasopharyngeal Carcinoma Survivors of Reproductive Age
Journal
Medicine (United States)
Journal Volume
95
Journal Issue
20
Date Issued
2016
Author(s)
Abstract
This study evaluated the pregnancy incidence in female nasopharyngeal carcinoma (NPC) survivors of reproductive age. In a nationwide cohort, 2816 female patients 15 to 50 years of age from 1998 to 2010 were identified from the Taiwan National Health Insurance Research database. Comorbidities, complications during pregnancy, and delivery status were recorded. All patients were followed up until a diagnosis of pregnancy, withdrawal from the National Health Insurance system, or December 31, 2011. Overall, 155 patients (incidence rate [IR]=9.50) were pregnant in the NPC group, whereas 251 patients (IR=12.80) were pregnant in the non-NPC group. The cumulative incidence of pregnancy in the NPC group was lower than that in the non-NPC group (incidence rate ratio=0.74, 95% CI=0.61-0.91). The adjusted hazard ratio of pregnancy in the NPC group was 0.79 with 95% CI=0.61-0.96, compared with the non-NPC group. The incidence of pregnancy is significantly lower among female NPC survivors of reproductive age than among those without NPC. ? 2016 Wolters Kluwer Health, Inc. All rights reserved.
SDGs
Other Subjects
antineoplastic agent; abortion; adolescent; adult; Article; blue collar worker; cancer chemotherapy; cancer radiotherapy; cancer survivor; comorbidity; controlled study; ectopic pregnancy; female; female infertility; follow up; human; major clinical study; maternal age; nasopharynx carcinoma; pregnancy outcome; pregnancy rate; priority journal; reproductive health; white collar worker; age; case control study; induced abortion; Infertility, Female; middle aged; Nasopharyngeal Neoplasms; occupation; pregnancy; Pregnancy, Ectopic; statistics and numerical data; survivor; Taiwan; young adult; Abortion, Induced; Adult; Age Factors; Case-Control Studies; Female; Humans; Infertility, Female; Middle Aged; Nasopharyngeal Neoplasms; Occupations; Pregnancy; Pregnancy Rate; Pregnancy, Ectopic; Survivors; Taiwan; Young Adult
Type
journal article