Renal Replacement Therapy in Patients with Influenza Pneumonia Related Acute Respiratory Distress Syndrome
Journal
Journal of clinical medicine
Journal Volume
10
Journal Issue
9
Date Issued
2021-04-23
Author(s)
Chang, Ko-Wei
Leu, Shaw-Woei
Lin, Shih-Wei
Liang, Shinn-Jye
Yang, Kuang-Yao
Chan, Ming-Cheng
Chen, Wei-Chih
Hu, Han-Chung
Fang, Wen-Feng
Chen, Yu-Mu
Sheu, Chau-Chyun
Tsai, Ming-Ju
Peng, Chung-Kan
Wu, Chieh-Liang
Kao, Kuo-Chin
Tsirc Taiwan Severe Influenza Research Consortium, null
Abstract
Acute kidney injury (AKI) requiring renal replacement therapy (RRT) increases the mortality of acute respiratory distress syndrome (ARDS) patients. The aim of this study was to investigate the outcomes and predictors of RRT in patients with influenza pneumonia-related ARDS. This retrospective cohort study includes patients from eight tertiary referral centers in Taiwan between January and March 2016, and all 282 patients with influenza pneumonia-related ARDS were enrolled. Thirty-four patients suffered from AKI requiring RRT, while 16 patients had underlying end stage renal disease (ESRD). The 30- and 60-day mortality rates were significantly higher in patients with AKI requiring RRT compared with those not requiring RRT (50.0% vs. 19.8%, p value < 0.001; 58.8% vs. 27.2%, p value = 0.001, respectively), but the patients with ESRD had no significant difference in mortality (12.5% vs. 19.8%, p value = 0.744; 31.3% vs. 27.2%, p value = 0.773, respectively). The predictors for AKI requiring RRT included underlying chronic liver disease and C-reactive protein. The mortality predictors for patients with AKI requiring RRT included the pneumonia severity index, tidal volume, and continuous renal replacement therapy. In this study, patients with influenza pneumonia-related ARDS with AKI requiring RRT had significantly higher mortality compared with other patients.
Subjects
acute respiratory distress syndrome; influenza; renal replacement therapy
Acute respiratory distress syndrome; Influenza; Renal replacement therapy
SDGs
Other Subjects
bilirubin; C reactive protein; hypertensive agent; acute kidney failure; adult; adult respiratory distress syndrome; APACHE; Article; bilirubin blood level; chronic liver disease; clinical outcome; cohort analysis; continuous renal replacement therapy; disease association; disease severity; end stage renal disease; female; hemodialysis; hospital mortality; human; influenza; intensive care unit; length of stay; major clinical study; male; metabolic acidosis; middle aged; mortality rate; peak airway pressure; pneumonia; Pneumonia Severity Index; predictor variable; renal replacement therapy; respiratory failure; retrospective study; survival; Taiwan; tertiary care center; tidal volume
Type
journal article