https://scholars.lib.ntu.edu.tw/handle/123456789/559513
標題: | Liver fibrosis associated with potential vinyl chloride and ethylene dichloride exposure from the petrochemical industry Yuan T.-H. Chen J.-L. Shie R.-H. Yeh Y.-P. Chen Y.-H. CHANG-CHUAN CHAN |
作者: | Yuan T.-H. Chen J.-L. Shie R.-H. Yeh Y.-P. Chen Y.-H. CHANG-CHUAN CHAN |
關鍵字: | Ethylene dichloride; Liver fibrosis; Petrochemical industry; Thiodiglycolic acid; Vinyl chloride | 公開日期: | 2020 | 出版社: | Elsevier B.V. | 卷: | 739 | 來源出版物: | Science of the Total Environment | 摘要: | Background: The understanding of the relationship between exposure to carcinogenic vinyl chloride (VCM) and ethylene dichloride (EDC) and liver fibrosis is limited. Objective: This study aimed to investigate the associations between the urinary metabolite levels of VCM and EDC and the risk of liver fibrosis in residents living near a petrochemical complex. Methods: Our study comprised 447 adult residents of two townships with questionnaire survey and health examination near the largest petrochemical complex in central Taiwan. The urinary levels of thiodiglycolic acid (TdGA), the metabolite of VCM and EDC, were detected in study subjects. We utilized fibrosis-4 (FIB-4) as the noninvasive liver fibrosis index. Adjusted linear model was applied to evaluate the associations between the distance from the complex and the urinary TdGA levels. Adjusted logistic regression model was applied to evaluate the associations between the urinary TdGA levels and the risk of liver fibrosis. Results: The study subjects living in the closer township had significant higher urinary TdGA levels than those living in the more distant township (269.6 ± 200.7 vs. 199.2 ± 164.7 μg/g creatinine) (p < 0.001). It showed that urinary TdGA levels were decreased 0.53-fold when the distances from the complex were increased 1-fold after adjusting for confounding factors. It demonstrated that the study subjects with the highest TdGA levels (>343.3 μg/g creatinine) had a higher risk of FIB-4>1.29 (OR = 2.09; 95% CI: 1.17, 3.78), and those with higher TdGA levels (232.7 to 343.3 μg/g creatinine) had a marginally higher risk of FIB-4>1.29 (OR = 1.65; 95% CI: 0.94, 2.90). Conclusion: The residents living closer to the VCM/PVC plant in the petrochemical complex had higher urinary TdGA levels, which were associated with an increased risk of fibrosis. This confirmed that the EDC and VCM potentially emitted from the petrochemical industry may have an impact on the liver health of nearby residents. ? 2020 Elsevier B.V. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85086144909&doi=10.1016%2fj.scitotenv.2020.139920&partnerID=40&md5=f8e68a1fd978bb49216762f3d3ca8a00 https://scholars.lib.ntu.edu.tw/handle/123456789/559513 |
ISSN: | 0048-9697 | DOI: | 10.1016/j.scitotenv.2020.139920 | SDG/關鍵字: | Aliphatic compounds; Chlorine compounds; Ethylene; Logistic regression; Metabolites; Petrochemical plants; Polyols; Surveys; Ethylene dichloride; Health examinations; Logistic Regression modeling; Petrochemical complex; Petrochemical industry; Questionnaire surveys; Thiodiglycolic acid; Urinary metabolites; Petrochemicals; 1,2 dichloroethane; creatinine; glycolic acid; thiodiglycolic acid; unclassified drug; vinyl chloride; 1,2 dichloroethane; chloride; ethylene; health impact; health risk; metabolite; petrochemical industry; urine; adult; aqueous solution; Article; controlled study; demography; female; fibrosis 4; hepatobiliary parameters; high performance liquid chromatography; human; liver biopsy; liver fibrosis; logistic regression analysis; male; mass spectrometry; measurement accuracy; medical examination; multiple reaction monitoring; petrochemical industry; population research; priority journal; questionnaire; risk factor; social status; industry; liver cirrhosis; Taiwan; Taiwan; Adult; Ethylene Dichlorides; Humans; Industry; Liver Cirrhosis; Taiwan; Vinyl Chloride |
顯示於: | 環境與職業健康科學研究所 |
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