Long-term Outcome of Endovascular Treatment for Mycotic Aortic Aneurysm
Journal
European Journal of Vascular and Endovascular Surgery
Journal Volume
54
Journal Issue
4
Pages
464-471
Date Issued
2017
Author(s)
Abstract
Objective/Background Endovascular repair (EVAR) of mycotic aortic aneurysm (MAA) has become an alternative treatment for high risk patients. The aim of this study was to evaluate long-term survival and outcomes. Methods Retrospective analysis of 40 consecutive patients with MAAs undergoing EVAR and subsequent intravenous antibiotic treatment between September 2009 and April 2015. Follow-up was truncated on 30 April 2015. Uni- and multivariate logistic regression were used to assess risk factors of adverse outcomes. Cumulative survival was calculated using the Kaplan–Meier method. Results Median age at repair was 73 years (range 48–88 years) and 31 (77%) were men. Eleven (27%) patients were infected with Salmonella, 12 (30%) with non-Salmonella species, and 17 (42%) had negative cultures. Anatomical locations included the aortic arch/thoracic area in 10 (25%), the paravisceral area in seven (17%), and the infrarenal area in 23 (57%). Ten (25%) patients presented with aneurysm rupture and underwent emergency repair. Median follow-up was 25 months (range 1–69 months). Cumulative 1 and 5 year survival rates were 71% and 53%, respectively. Persistent or recurrent infection occurred in 20% (n = 8). Patients with persistent infection were treated with long-term medical therapy, but all died (75%; n = 6) within 6 months of repair. No survival difference was found between patients with or without Salmonella infections. However, there was a trend toward better survival in culture negative patients. Conclusion EVAR of MAA is an acceptable alternative treatment of MAA. However, persistent infection after endovascular treatment does occur and is often fatal without surgical treatment. ? 2017 European Society for Vascular Surgery
SDGs
Other Subjects
antibiotic agent; ceftriaxone; antiinfective agent; adult; aged; anatomic landmark; aneurysm rupture; antibiotic therapy; aortic aneurysm; aortic arch; Article; clinical article; clinical outcome; emergency surgery; endovascular aneurysm repair; female; follow up; human; Kaplan Meier method; long term care; long term survival; male; multivariate logistic regression analysis; mycotic aneurysm; persistent infection; priority journal; recurrent infection; retrospective study; risk factor; Salmonella; salmonellosis; survival rate; univariate analysis; endovascular surgery; infected aneurysm; microbiology; middle aged; mortality; thoracic aorta aneurysm; treatment outcome; very elderly; Aged; Aged, 80 and over; Aneurysm, Infected; Anti-Bacterial Agents; Aortic Aneurysm, Thoracic; Endovascular Procedures; Female; Humans; Male; Middle Aged; Retrospective Studies; Survival Rate; Treatment Outcome
Publisher
W.B. Saunders Ltd
Type
journal article