Risk factor screening scale to optimize treatment for potential heart transplant candidates under extracorporeal membrane oxygenation
Journal
American Journal of Transplantation
Journal Volume
4
Journal Issue
11
Pages
1818-1825
Date Issued
2004
Author(s)
Ko W.-J.
Chen R.J.-C.
Lin F.-Y.
Chu S.-H.
Abstract
We developed a risk factor-scaling score (RFSS) to select which patients supported by extracorporeal membrane oxygenation (ECMO) were suitable for ventricular assist device (VAD) implantation or heart transplantation (HTx). A total of 78 patients supported with ECMO for more than 48 h due to cardiac origin were included in this study. Patients were categorized into two groups based on the outcomes: the poor outcome group (n = 33) consisted of for those who later died or were later excluded from VAD or HTx; the favorable outcome group (n = 45) consisted of those who were weaned off ECMO finally and survived or were deemed suitable candidates for VAD or HTx. Seven risk factors were significant according to univariate analyses. Based on the regression coefficients of multivariate analysis, the RFSS was developed: (lung dysfunction × 7) + (systemic infection ×) + (peak lactate > 3 mmole/L × 3) + (kidney dysfunction × 2) + (creatine kinase > 10 000 U/L × 1). Patients with an RFSS of 7 or more were be allocated to the poor outcome group. The RFSS was validated by another group of 30 patients with good correlation. The RFSS provides a way to predict which ECMO-supported patients are suitable candidates for VAD implantation or HTx.
SDGs
Other Subjects
adolescent; adult; aged; article; assisted circulation; diagnostic value; extracorporeal oxygenation; female; heart transplantation; human; implantation; lung disease; major clinical study; male; multivariate analysis; outcomes research; patient selection; priority journal; process optimization; regression analysis; resource allocation; risk factor; risk factor scaling score; scoring system; screening test; statistical significance; survival; treatment outcome; validation process; Adolescent; Adult; Aged; Blood Cell Count; Blood Chemical Analysis; Blood Urea Nitrogen; Extracorporeal Membrane Oxygenation; Female; Heart Transplantation; Heart-Assist Devices; Humans; Male; Middle Aged; Probability; Reproducibility of Results; Risk Factors; Survival Analysis; Treatment Failure; Treatment Outcome; Ventilator Weaning
Type
journal article