https://scholars.lib.ntu.edu.tw/handle/123456789/560306
標題: | Low Incidence of Malignancy after Heart Transplantation in Taiwan | 作者: | Wang Y.-J. NAI-HSIN CHI NAI-KUAN CHOU SHU-CHIEN HUANG CHIH-HSIEN WANG I-HUI WU HSI-YU YU YIH-SHARNG CHEN Tsao C.-I. CHIA-TUNG SHUN Tsai J.-T. SHOEI-SHEN WANG |
公開日期: | 2016 | 出版社: | Elsevier USA | 卷: | 48 | 期: | 3 | 起(迄)頁: | 974-977 | 來源出版物: | Transplantation Proceedings | 摘要: | Background Malignancy is the leading cause of death in Taiwan. The risk of malignancy is higher in heart transplant recipients than in the general population. We reviewed the malignancy incidence among the patients who underwent heart transplantation (HT) at the National Taiwan University Hospital (NTUH) during the past 28 years. We found that the incidence of malignancy is low in Taiwan and that the pattern of malignancy is different from that in the Western population. Methods From July 1987 to March 2015, 518 patients underwent HT at NTUH. Forty-four patients who died within 1 month after transplantation were excluded from this study. Thus, a total of 476 patients were enrolled in this study. There were 393 male and 83 female patients, with a mean age of 45 years at transplantation. The major indications for HT were dilated cardiomyopathy (52%) and ischemic cardiomyopathy (33%). After HT, all patients received triple immunosuppressive therapy, including a calcineurin inhibitor (cyclosporine or tacrolimus), cell-cycle inhibitor (azathioprine, mycophenolate mofetil, or everolimus), and steroid. After 1995, induction with rabbit anti-human thymocyte globulin was routinely performed. Survival was estimated by means of the Kaplan-Meier method. Results Twenty-seven patients without pre-transplantation malignancy developed malignancies after HT. The median survival time (MST) of these 27 HT patients was 76.8 months. After malignancy was diagnosed, the overall MST was 20.7 months. The 3- and 5-year overall survival rates were 44% and 27%, respectively. Twenty-one patients (77.8%) died, 10 of them because of cancer. The most common malignancy was non-Hodgkin lymphoma (n = 6), followed by skin cancer (including 2 keratoacanthomas, 2 squamous cell carcinomas, and 1 basal cell carcinoma; n = 5) and lung squamous cell carcinoma (n = 3). The univariate analysis identified cancer stage (P =.044) and comorbidity (P =.002) as factors associated with poor malignancy survival. In the multivariate analysis, comorbidity was an independent prognostic factor for greater risk of death because of post-transplantation malignancy (P =.002). Conclusions In Taiwan, the risk of malignancy after HT is low (5.7%), as is the incidence of skin cancer. The most common malignancy was non-Hodgkin lymphoma, followed by skin cancer and lung cancer. Comorbidity was an independent factor for overall survival in cancer patients who previously underwent HT. ? 2016 Elsevier Inc. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84970024692&doi=10.1016%2fj.transproceed.2015.12.079&partnerID=40&md5=6c96b4556f01491c18ee27ad0f393e8f https://scholars.lib.ntu.edu.tw/handle/123456789/560306 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2015.12.079 | SDG/關鍵字: | azathioprine; cyclosporin; everolimus; mycophenolate mofetil; tacrolimus; adult; aged; Article; cancer incidence; cancer mortality; cancer palliative therapy; cancer patient; cancer prognosis; cancer recurrence; cancer staging; cancer surgery; cancer survival; comorbidity; congestive cardiomyopathy; female; heart transplantation; human; immunosuppressive treatment; ischemic cardiomyopathy; kidney function; lymphoma; major clinical study; male; malignant neoplastic disease; median survival time; middle aged; nonhodgkin lymphoma; outcome assessment; overall survival; priority journal; prostate cancer; skin cancer; squamous cell lung carcinoma; Taiwan; adverse effects; cause of death; heart transplantation; incidence; Neoplasms; survival rate; trends; young adult; Adult; Aged; Cause of Death; Female; Heart Transplantation; Humans; Immunosuppression; Incidence; Male; Middle Aged; Neoplasms; Survival Rate; Taiwan; Young Adult |
顯示於: | 醫學系 |
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