https://scholars.lib.ntu.edu.tw/handle/123456789/560348
Title: | Efficacy and safety of tacrolimus versus cyclosporine microemulsion in primary cardiac transplant recipients: 6-month results in Taiwan | Authors: | CHIH-HSIEN WANG Ko W.J. NAI-KUAN CHOU SHOEI-SHEN WANG |
Issue Date: | 2004 | Journal Volume: | 36 | Journal Issue: | 8 | Start page/Pages: | 2384-2385 | Source: | Transplantation Proceedings | Abstract: | This study compared the efficacy and safety of a tacrolimus (TAC)-based with a cyclosporine (CsA)microemulsion-based immunosuppressive regimen in primary cardiac transplantation. Heart recipients were randomly assigned to receive either TAC or CsA regimen after sequential induction with rabbit anti-thymoglobulin. Endomyocardial biopsies were performed at weeks 1, 2, 3, and 4 and months 2, 3, and 6. Among 21 adult patients (TAC, 11; CsA, 10) in this study, patient survival rates were 100% in both groups at the end of 6 months. One patient (9%) in the TAC group experienced acute rejection (ISHLT< 1B) versus 6 patients (60%) in the CsA group (P =. 02). The effects on hematology, biochemistry, cytomegalovirusinfection, and hemodynamics were similar in both groups except for better lipid profiles in the TAC group. There were no significant differences in severe adverse events. The TAC-based regimen had a lower risk of acute rejection compared with CsA in heart transplant recipients. The safety profiles were similar in both groups. Therefore, TAC is an alternative to CsA as a primary maintenance immunosuppressant in heart transplantation. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-9244231773&doi=10.1016%2fj.transproceed.2004.08.059&partnerID=40&md5=d3d4e24aca917f80de96c272ee1c9f5b https://scholars.lib.ntu.edu.tw/handle/123456789/560348 |
ISSN: | 0041-1345 | DOI: | 10.1016/j.transproceed.2004.08.059 | SDG/Keyword: | azathioprine; cyclosporin A; lipid; steroid; tacrolimus; thymocyte antibody; adult; biochemistry; clinical article; clinical trial; conference paper; controlled clinical trial; controlled study; cytomegalovirus infection; disease severity; drug efficacy; drug safety; female; glucose intolerance; graft rejection; heart muscle biopsy; heart transplantation; hematology; hemodynamics; human; immunosuppressive treatment; male; microemulsion; nephrotoxicity; neurotoxicity; priority journal; rabbit; randomization; randomized controlled trial; recipient; side effect; statistical significance; survival rate; time series analysis; Adult; Cyclosporine; Female; Graft Rejection; Humans; Immunosuppressive Agents; Lipids; Male; Middle Aged; Probability; Tacrolimus |
Appears in Collections: | 醫學系 |
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