Skip navigation
  • 中文
  • English

DSpace CRIS

  • DSpace logo
  • Home
  • Organizations
  • Researchers
  • Research Outputs
  • Explore by
    • Organizations
    • Researchers
    • Research Outputs
  • Academic & Publications
  • Sign in
  • 中文
  • English
  1. NTU Scholars
  2. 公共衛生學院
  3. 流行病學與預防醫學研究所
Please use this identifier to cite or link to this item: https://scholars.lib.ntu.edu.tw/handle/123456789/560515
Title: Adjuvant radiotherapy after curative surgery for oral cavity squamous cell carcinoma and treatment effect of timing and duration on outcome—A Taiwan Cancer Registry national database analysis
Authors: Cheng Y.-J.
Tsai M.-H.
CHUN-JU CHIANG 
Tsai S.-T.
Liu T.-W.
PEI-JEN LOU 
Liao C.-T.
Lin J.-C.
Chang J.T.-C.
Tsai M.-H.
Chu P.-Y.
Leu Y.-S.
Tsai K.-Y.
Terng S.-D.
Chien C.-Y.
Yang M.-H.
Hao S.-P.
Wang C.-C.
Tsai M.-H.
Chen H.H.W.
Kuo C.
Wu Y.-H.
Issue Date: 2018
Publisher: Blackwell Publishing Ltd
Journal Volume: 7
Journal Issue: 7
Start page/Pages: 3073-3083
Source: Cancer Medicine
Abstract: 
Conduct an accurate risk assessment of resected oral cavity squamous cell carcinoma (OSCC) patients by accessing a nationwide systemic investigation is pivotal to improve treatment outcomes. In this article, we tried to determine the impact of different prognostic factors for OSCC patients who received adjuvant radiotherapy (RT) after curative surgery, using Taiwan's national cancer registry database (TCR). A nationwide, large population-based study was conducted using TCR with patients identified from 2007 to 2015. The study variables included age, gender, cancer subsites, stage, histology grade, margin and extra-nodal extension (ENE) status, treatment type, surgery to RT interval (ORI), total RT treatment time (RTT), and RT dose. Univariate and multivariate analysis were performed to identify predictors of the variables associated with overall survival (OS), cause-specific survival (CSS), local-regional relapse-free survival (LRFS), and distant metastasis-free survival (DMFS). 8986 OSCC patients treated with surgery and adjuvant RT were analyzed. In multivariate analysis, worse outcomes were associated with males, older age, subsite in the oral tongue, advanced stage, higher histologic grade, involved margin, and positive ENE. ORI only showed an adverse trend in LRFS, when exceeding 7?weeks (P?=.06). RTT >8?weeks was a significant poor predictor in OS, CSS and LRFS (P?<.001). Extreme RT dose (>70?Gy or ?50?Gy) also demonstrated an adverse impact on the outcomes. Prolonged RT treatment time and extreme RT doses were identified as significantly poor prognostic predictors in OSCC patients who received adjuvant RT after curative surgery. ? 2018 The Authors. Cancer Medicine published by John Wiley & Sons Ltd.
URI: https://www.scopus.com/inward/record.uri?eid=2-s2.0-85050116949&doi=10.1002%2fcam4.1611&partnerID=40&md5=3d4986142ba5d2cbdf95ce4a24fc0375
https://scholars.lib.ntu.edu.tw/handle/123456789/560515
ISSN: 2045-7634
DOI: 10.1002/cam4.1611
SDG/Keyword: adjuvant radiotherapy; adult; age; aged; Article; cancer grading; cancer prognosis; cancer registry; cancer staging; cause specific survival; distant metastasis free survival; extranodal extension; female; human; local recurrence free survival; major clinical study; male; middle aged; mouth squamous cell carcinoma; oncological parameters; overall survival; priority journal; sex difference; surgical margin; Taiwan; tongue carcinoma
[SDGs]SDG3
Appears in Collections:流行病學與預防醫學研究所

Show full item record

SCOPUSTM   
Citations

19
checked on Mar 27, 2023

WEB OF SCIENCETM
Citations

16
checked on Mar 19, 2023

Page view(s)

37
checked on Mar 26, 2023

Google ScholarTM

Check

Altmetric

Altmetric

Related Items in TAIR


Items in DSpace are protected by copyright, with all rights reserved, unless otherwise indicated.

臺大位居世界頂尖大學之列,為永久珍藏及向國際展現本校豐碩的研究成果及學術能量,圖書館整合機構典藏(NTUR)與學術庫(AH)不同功能平台,成為臺大學術典藏NTU scholars。期能整合研究能量、促進交流合作、保存學術產出、推廣研究成果。

To permanently archive and promote researcher profiles and scholarly works, Library integrates the services of “NTU Repository” with “Academic Hub” to form NTU Scholars.

總館學科館員 (Main Library)
醫學圖書館學科館員 (Medical Library)
社會科學院辜振甫紀念圖書館學科館員 (Social Sciences Library)

開放取用是從使用者角度提升資訊取用性的社會運動,應用在學術研究上是透過將研究著作公開供使用者自由取閱,以促進學術傳播及因應期刊訂購費用逐年攀升。同時可加速研究發展、提升研究影響力,NTU Scholars即為本校的開放取用典藏(OA Archive)平台。(點選深入了解OA)

  • 請確認所上傳的全文是原創的內容,若該文件包含部分內容的版權非匯入者所有,或由第三方贊助與合作完成,請確認該版權所有者及第三方同意提供此授權。
    Please represent that the submission is your original work, and that you have the right to grant the rights to upload.
  • 若欲上傳已出版的全文電子檔,可使用Sherpa Romeo網站查詢,以確認出版單位之版權政策。
    Please use Sherpa Romeo to find a summary of permissions that are normally given as part of each publisher's copyright transfer agreement.
  • 網站簡介 (Quickstart Guide)
  • 使用手冊 (Instruction Manual)
  • 線上預約服務 (Booking Service)
  • 方案一:臺灣大學計算機中心帳號登入
    (With C&INC Email Account)
  • 方案二:ORCID帳號登入 (With ORCID)
  • 方案一:定期更新ORCID者,以ID匯入 (Search for identifier (ORCID))
  • 方案二:自行建檔 (Default mode Submission)
  • 方案三:學科館員協助匯入 (Email worklist to subject librarians)
Build with DSpace-CRIS - Extension maintained and optimized by Logo 4SCIENCE Feedback