The B cell inhibitory Fc receptor triggers apoptosis by a novel c-Abl family kinase-dependent pathway
Journal
Journal of Biological Chemistry
Journal Volume
280
Journal Issue
42
Pages
35247-35254
Date Issued
2005
Author(s)
Abstract
The inhibitory Fc receptors function to regulate the antigen-driven activation and expansion of lymphocytes. In B cells, the FcγRIIB1 is a potent inhibitor of B cell antigen receptor (BCR) signaling when coligated to the BCR by engagement of antigen-containing immune complexes. Inhibition is mediated by the recruitment of the inositol phosphatase, SHIP, to the FcγRIIB1 phosphorylated tyrosine-based inhibitory motif (ITIM). Here we show that BCR-independent aggregation of the FcγRIIB1 transduces an ITIM- and SHIP-independent proapoptotic signal that is dependent on members of the c-Abl tyrosine kinase family. These results define a novel Abl family kinase-dependent FcγRIIB1 signaling pathway that functions independently of the BCR in controlling antigen-driven B cell responses.
SDGs
Type
journal article