|Title:||The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway||Authors:||Lee, S.-C.
|Keywords:||Proline-directed protein kinase FA/GSK-3a;protein kinase c;sphingosine;TPA;signal transduction;tyrosine phosphorylation||Issue Date:||1998||Publisher:||Plenum Publishing Corporation||Journal Volume:||17||Journal Issue:||1||Start page/Pages:||15-27||Source:||Journal of Protein Chemistry||Abstract:||
When serum-starved A431 cells were treated with 200 nM phorbol ester TPA for 15 min, the cellular activity of protein kinase FA/glycogen synthase kinase-3alpha (kinase FA/GSK-3alpha) could be decreased to approximately 25% of control. Conversely, when treated with 1 microM TPA for 24 hr, the activity could be reversibly increased to approximately 200% of Control.
|Appears in Collections:||分子與細胞生物學研究所|
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