https://scholars.lib.ntu.edu.tw/handle/123456789/560924
Title: | The naturally occurring PKC inhibitor sphingosine and tumor promoter phorbol ester potentially induce tyrosine phosphorylation/activation of oncogenic proline-directed protein kinase FA/GSK-3alpha in a common signalling pathway | Authors: | Lee, S.-C. Kuan, C.-Y. Wen, Z.-D. Yang, S.-D. |
Keywords: | Proline-directed protein kinase FA/GSK-3a;protein kinase c;sphingosine;TPA;signal transduction;tyrosine phosphorylation | Issue Date: | 1998 | Publisher: | Plenum Publishing Corporation | Journal Volume: | 17 | Journal Issue: | 1 | Start page/Pages: | 15-27 | Source: | Journal of Protein Chemistry | Abstract: | When serum-starved A431 cells were treated with 200 nM phorbol ester TPA for 15 min, the cellular activity of protein kinase FA/glycogen synthase kinase-3alpha (kinase FA/GSK-3alpha) could be decreased to approximately 25% of control. Conversely, when treated with 1 microM TPA for 24 hr, the activity could be reversibly increased to approximately 200% of Control. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/560924 | DOI: | 10.1023/a:1022582312954 |
Appears in Collections: | 分子與細胞生物學研究所 |
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