https://scholars.lib.ntu.edu.tw/handle/123456789/561157
標題: | Clinical and genotypic characteristics of extensively drug-resistant and multidrug-resistant tuberculosis | 作者: | Lai C.C. Tan C.K. Lin S.H. Liao C.H. YU-TSUNG HUANG Chou C.H. Hsu H.L. Wang C.Y. Lin H.I. PO-REN HSUEH |
公開日期: | 2010 | 卷: | 29 | 期: | 5 | 起(迄)頁: | 597-600 | 來源出版物: | European Journal of Clinical Microbiology and Infectious Diseases | 摘要: | The aims of this study were to compare the clinical features of patients with extensively drug-resistant tuberculosis (XDRTB) and multidrug-resistant tuberculosis (MDRTB) and the genotypic characteristics of these Mycobacterium tuberculosis isolates. A total of 90 non-HIV-infected patients having MDRTB (n = 80, not including XDRTB, 88.9%) and XDRTB (n = 10, 11.1%) were identified from 2000 to 2007. Genotypes of the 39 available isolates were evaluated by spoligotyping and the 24-locus mycobacterial interspersed repetitive units-variable number of tandem repeats (MIRU-VNTR) scheme. Patients with XDRTB were more likely to have previous history of TB and cavitary lung lesions than patients with MDRTB (P < 0.05). Among the 39 isolates for spoligotyping analysis, the Beijing genotype was the most common (n = 21, 53.8%). Four (44.4%) isolates of XDRTB and 17 (56.7%) isolates of MDRTB belonged to Beijing family genotypes. There was no significant difference in the anti-tuberculosis drug resistance rates between Beijing and non-Beijing genotype isolates or in the clinical features of infected patients. In conclusion, significant differences in clinical manifestations existed among patients with XDRTB and MDRTB. The clinical features of patients infected with the Beijing genotype and the drug resistance profile of the Beijing genotype isolates were similar to those for the non-Beijing family genotype. ? 2010 Springer-Verlag. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561157 | ISSN: | 0934-9723 | DOI: | 10.1007/s10096-010-0874-6 | SDG/關鍵字: | amikacin; aminoglycoside; aminoglycoside derivative; capreomycin; levofloxacin; moxifloxacin; ofloxacin; quinoline derived antiinfective agent; streptomycin; adult; antibiotic resistance; article; bacterial gene; bacterium isolate; China; clinical feature; controlled study; cross resistance; extensively drug resistant tuberculosis; female; gene locus; genetic analysis; genetic difference; genetic trait; genetic variability; genotype; human; interspersed repeat; lung lesion; major clinical study; male; multidrug resistant tuberculosis; Mycobacterium tuberculosis; nonhuman; priority journal; variable number of tandem repeat; Adult; Aged; Cluster Analysis; Drug Resistance, Multiple, Bacterial; Extensively Drug-Resistant Tuberculosis; Female; Humans; Male; Middle Aged; Minisatellite Repeats; Mycobacterium tuberculosis; Polymerase Chain Reaction; Tuberculosis, Multidrug-Resistant |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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