https://scholars.lib.ntu.edu.tw/handle/123456789/561408
標題: | Withaferin A protects against endoplasmic reticulum stress-associated apoptosis, inflammation, and fibrosis in the kidney of a mouse model of unilateral ureteral obstruction | 作者: | CHANG-MU CHEN Chung, Yao-Pang Liu, Chia-Hung Huang, Kuo-Tong Guan, Siao-Syun CHIH-KANG CHIANG Wu, Chen-Tien SHING-HWA LIU |
關鍵字: | Apoptosis; Chronic kidney disease; ER stress; Inflammation; Withaferin A | 公開日期: | 十二月-2020 | 卷: | 79 | 來源出版物: | Phytomedicine : international journal of phytotherapy and phytopharmacology | 摘要: | Withaferin A is a functional ingredient of a traditional medicinal plant, Withania somnifera, which has been broadly used in India for protecting against chronic diseases. This bioactive steroidal lactone possesses multiple functions such as anti-oxidation, anti-inflammation, and immunomodulation. Chronic kidney disease (CKD) is one of the major health problems worldwide with the high complication, morbidity, and mortality rates. The detailed effects and underlying mechanisms of withaferin A on CKD progression still remain to be clarified. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/561408 | ISSN: | 09447113 | DOI: | 10.1016/j.phymed.2020.153352 |
顯示於: | 醫學系 |
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