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  4. Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat
 
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Green tea extract induces genes related to browning of white adipose tissue and limits weight-gain in high energy diet-fed rat

Journal
Food & Nutrition Research
Journal Volume
61
Journal Issue
1
Pages
1347480
Date Issued
2017
Author(s)
Li-Han Chen  
Yi-Wen Chien
Chung-Tiang Liang
Ching-Hung Chan
Meng-Han Fan
Hui-Yu Huang
DOI
10.1080/16546628.2017.1347480
URI
https://scholars.lib.ntu.edu.tw/handle/123456789/561628
Abstract
Background: A wealth of research has reported on the anti-obesity effects of green tea extract (GTE). Although browning of white adipose tissue (WAT) has been reported to attenuate obesity, no study has disclosed the effects of GTE on browning in Sprague Dawley rats. Objectives: The aims of the study were to investigate the effects of GTE on anti-obesity and browning, and their underlying mechanisms. Methods: Four groups of rats (n=10/group) were used including a normal diet with vehicle treatment, and a high-energy diet (HED) with vehicle or GTE by oral gavage at 77.5 or 155 mg/kg/ day for 8 weeks. Body weight, fat accumulation, and serum biochemical parameters were used to evaluate obesity. The gene expressions were analyzed using RT-qPCR and western blotting. Results: GTE modulated HED-induced body weight, fat accumulation, and serum levels of triacylglycerol, total cholesterol, low-density lipoprotein, free fatty acids, aspartate aminotransferase, and alanine aminotransferase. Moreover, GTE enhanced the serum high-density lipoprotein. Most importantly, the biomarkers of beige adipose tissue were up-regulated in WAT in GTE-given groups. GTE induced genes involved in different pathways of browning, and reduced transducin-like enhancer protein-3 in WAT. Conclusion: Our results suggest that GTE may improve obesity through inducing browning in HED-fed rats. ? 2017 The Author(s).
Subjects
Anti-obesity; Beige adipose tissue; Browning of white adipose tissue; Green tea extract; Pathways of browning
SDGs

[SDGs]SDG3

Other Subjects
alanine aminotransferase; aspartate aminotransferase; cholesterol; fatty acid; high density lipoprotein; low density lipoprotein; sinecatechins; transcription factor; transducin like enhancer protein 3; triacylglycerol; unclassified drug; alanine aminotransferase blood level; animal cell; animal experiment; animal model; animal tissue; antiobesity activity; Article; aspartate aminotransferase blood level; beige adipose tissue; body weight; body weight control; cholesterol blood level; controlled study; fatty acid blood level; gene expression; high calorie diet; high density lipoprotein cholesterol level; lipid storage; low density lipoprotein cholesterol level; male; nonhuman; obesity; rat; real time reverse transcription polymerase chain reaction; treatment duration; triacylglycerol blood level; upregulation; Western blotting; white adipose tissue
Publisher
Swedish Nutrition Foundation
Type
journal article

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