Incidence of chronic thromboembolic pulmonary hypertension in Taiwan
Journal
Journal of the Formosan Medical Association
Date Issued
2021
Author(s)
Liu H.-Y.
TZU-PIN LU
Tao C.-W.
Wu Y.-J.
Huang W.-C.
Hsu C.-H.
Liao W.-C.
HSAO-HSUN HSU
Lin M.-C.
CHONG-JEN YU
Abstract
Background: The diagnosis of chronic thromboembolic pulmonary hypertension (CTEPH) is complex, and the modality of treatment is surgery and targeted medication. Patients with CTEPH could have a poor prognosis if their diagnosis or treatment is delayed. The incidence of CTEPH and its clinical features are largely unknown in Taiwan, even among other Asian populations. In this study, we aimed to investigate the geodemographics of CTEPH in Taiwan and describe the practical management and treatment outcomes in patients with CTEPH. Methods: This study retrospectively enrolled patients in the Taiwan cohort – Registry of CTEPH. The study was conducted over 2 years inclusive of follow-up. The enrolment criteria depended on the current global guideline. Results: From January 2018 to March 2020, 107 CTEPH patients enrolled in the Taiwan registry. All patients received right heart catheterisation examinations. The overall median age was 61.4 ± 16.5 years, and the cohort was dominated by female patients (75/107). Risk factors included pulmonary embolism (81.3%), deep vein thrombosis (22.4%), and previous major surgery (20.6%). Twenty-one (19.6%) patients underwent pulmonary endarterectomy operation alone, and 38 (35.5%) patients underwent balloon pulmonary angioplasty alone. Conclusion: To our knowledge, this is the first national cohort study that demonstrated the raw CTEPH incidence in Taiwan. It also showed the CTEPH incidence between male and female patients in the Asian population was different from the Caucasian population. ? 2021
SDGs
Other Subjects
amino terminal pro brain natriuretic peptide; anticoagulant agent; brain natriuretic peptide; guanylate cyclase activator; phosphodiesterase V inhibitor; adult; age; angioplasty; anticoagulant therapy; Article; Asian; balloon pulmonary angioplasty; Caucasian; chronic thromboembolic pulmonary hypertension; clinical feature; cohort analysis; comorbidity; computed tomographic angiography; current smoker; deep vein thrombosis; demography; descriptive research; dyslipidemia; echocardiography; ex-smoker; female; follow up; geography; heart catheterization; human; hypertension; incidence; leg edema; lung angiography; lung artery pressure; lung embolism; major clinical study; major surgery; male; middle aged; multicenter study; patient selection; practice guideline; pulmonary artery occlusion pressure; pulmonary endarterectomy; register; retrospective study; risk factor; sex difference; six minute walk test; Taiwan; telephone interview; thorax radiography; treatment outcome; tricuspid valve regurgitation; aged; chronic disease; endarterectomy; incidence; lung embolism; pulmonary hypertension; Adult; Aged; Chronic Disease; Cohort Studies; Endarterectomy; Female; Humans; Hypertension, Pulmonary; Incidence; Male; Middle Aged; Pulmonary Embolism; Retrospective Studies; Taiwan
Publisher
Elsevier B.V.
Type
journal article