https://scholars.lib.ntu.edu.tw/handle/123456789/562550
標題: | Invasive infections due to vancomycin-resistant enterococci in adult patients | 作者: | Jean S.-S. CHI-TAI FANG Wang H.-K. PO-REN HSUEH SHAN-CHWEN CHANG KWEN-TAY LUH |
公開日期: | 2001 | 卷: | 34 | 期: | 4 | 起(迄)頁: | 281-286 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Since 1990, vancomycin-resistant enterococci have emerged as important nosocomial pathogens. Invasive infections caused by these organisms have challenged most physicians because they are resistant to multiple antibiotics. We analyzed the clinical characteristics of adult patients with invasive vancomycin- resistant enterococci infections in the National Taiwan University Hospital from January 1993 through December 2000. A total of 11 adult patients were identified, 9 of whom had bacteremia (7 caused by vancomycin-resistant Enterococcus faecalis and 2 by vancomycin-resistant Enterococcus faecium) and one each had thoracic empyema (vancomycin-resistant E. faecium) and peritonitis (vancomycin-resistant E. faecium). Five patients had rectal swab cultures positive for vancomycin-resistant enterococci; 4 of them had underlying malignancies. The majority (91%) of these patients had prolonged hospitalization and prior long-term use of broad-spectrum cephalosporins (ceftriaxone, ceftazidime, or cefepime) or anti-anaerobic agents (clindamycin or metronidazole). The crude mortality rate was 64%. In conclusion, invasive infection caused by vancomycin-resistant enterococci is an emerging problem among hospitalized patients in Taiwan, particularly those with severe underlying diseases and exposure to multiple antibiotics. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562550 | ISSN: | 0253-2662 | SDG/關鍵字: | cefepime; ceftazidime; ceftriaxone; clindamycin; metronidazole; vancomycin; adult; aged; antibiotic resistance; article; bacteremia; bacterial infection; bacterial peritonitis; clinical article; Enterococcus; Enterococcus faecalis; Enterococcus faecium; feces culture; female; hospital infection; human; male; mortality; pleura empyema; Taiwan; Adult; Aged; Drug Resistance, Bacterial; Enterococcus faecalis; Enterococcus faecium; Female; Gram-Positive Bacterial Infections; Humans; Male; Middle Aged; Prospective Studies; Vancomycin |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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