https://scholars.lib.ntu.edu.tw/handle/123456789/562584
標題: | In vitro activity of rifabutin and rifampin against clinical isolates of Mycobacterium tuberculosis in Taiwan | 作者: | Chien H.-P. Yu M.-C. Ong T.-F. Lin T.-P. KWEN-TAY LUH |
關鍵字: | Multidrug resistance; Mycobacterium tuberculosis; Rifabutin; Rifampin | 公開日期: | 2000 | 卷: | 99 | 期: | 5 | 起(迄)頁: | 408-411 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Background and purpose: To determine the in vitro activity of rifabutin against Mycobacterium tuberculosis (MTB) and the cross-resistance rate between rifampin and rifabutin. Methods:A total of 56 clinical isolates of MTB, including 23 multidrug-resistant (MDR) isolates and 33 susceptible isolates, were tested for susceptibility to rifampin and rifabutin using the absolute concentration method. The concentrations of drugs tested were 2.5 and 5 mg/mL for rifampin and 0.1, 0.5, 1, 2,5, 5, and 10 mg/mL for rifabutin. Results: All 33 MTB isolates that were susceptible to rifampin were also susceptible to rifabutin. None of the 23 MDR-MTB isolates were inhibited by rifabutin at a concentration of 0.1 mg/mL. Among these 23 MDR isolates, three were susceptible to rifabutin at concentrations ? 0.5 mg/mL, six were susceptible to rifabutin at concentrations ? 5 mg/mL, 18 were susceptible to rifabutin at concentrations ? 10 mg/mL and five were not inhibited at any of the concentrations tested. The cross-resistance rate between rifampin and rifabutin was 87%. Conclusions: Our results indicate that the in vitro activity of rifabutin against drug- susceptible MTB isolates is greater than that of rifampin. For MDR-MTB isolates, the cross-resistance is high between rifampin and rifabutin. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562584 | ISSN: | 0929-6646 | SDG/關鍵字: | rifabutin; rifampicin; antibiotic sensitivity; article; bacterium isolate; cross resistance; in vitro study; multidrug resistance; Mycobacterium tuberculosis; nonhuman; tuberculosis; Antibiotics, Antitubercular; Drug Resistance, Microbial; Humans; Microbial Sensitivity Tests; Mycobacterium tuberculosis; Rifabutin; Rifampin |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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