https://scholars.lib.ntu.edu.tw/handle/123456789/562645
標題: | Tumour-infiltrating lymphocytes in non-small cell lung cancer are activated T lymphocytes | 作者: | Kuo S.-H. Chang D.-B. Lee Y.-C. KWEN-TAY LUH |
關鍵字: | Activated memory lymphocyte; Non-small cell lung cancer; Tumour- infiltrating lymphocyte | 公開日期: | 1998 | 卷: | 3 | 期: | 1 | 起(迄)頁: | 55-59 | 來源出版物: | Respirology | 摘要: | This study was carried out in order to investigate the local immune reaction of tumour infiltrating lymphocytes (TILs) in the primary tumours of non-small cell lung carcinomas. Thirty non-small cell lung cancer (NSCLC) patients were included. The tumour tissue was taken at thoracotomy and monocellular suspension of the tumour was obtained by mechanical disaggregation. Dual-coloured flow cytometric analysis of TILs and their corresponding peripheral blood lymphocytes (PBLs) was performed. Tumour- infiltrating lymphocytes contained significantly higher proportions of CD3(+) T lymphocytes and CD8(+) T lymphocytes than the corresponding PBLs (82.0% ± 13.9% us 66.3% ±10.6% for CD3, P<0.001; 39.0% ± 18.4% vs 26.4% ± 5.2% for CD8, P<0.001). Tumour-infiltrating lymphocytes contained significantly higher proportions of activated memory lymphocytes than PBLs did (9.8% ±8.6% vs 1.3% ± 1.5% for CD25, P<0.001; 40.5% ± 30.2% us 10.2% ± 14.8% for CD71, P<0.001; 75.5% ± 11.9% vs 28.6% ± 9.8% for HLA-DR, P<0.001). These findings were also found in both CD4(+) TILs and CD8(+) TILs. The TILs of NSCLC contained higher proportions oft lymphocytes and CDS(+) lymphocytes than their corresponding peripheral bloods. The proportions of activated memory lymphocytes were also significantly higher in the TILs, both in CD4(+) TILs and CD8(+) TILs, than the corresponding PBLs. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562645 | ISSN: | 1323-7799 | DOI: | 10.1046/j.1440-1843.1998.d01-9.x | SDG/關鍵字: | adult; aged; article; cancer immunology; cell infiltration; clinical article; human; lung non small cell cancer; lymphocyte activation; priority journal; T lymphocyte |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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