https://scholars.lib.ntu.edu.tw/handle/123456789/562889
標題: | Overexpression of 14-3-3ε predicts tumour metastasis and poor survival in hepatocellular carcinoma | 作者: | BOR-SHENG KO Chang T.-C. CHIUN HSU YAO-CHANG CHEN Shen T.-L. Chen S.-C. Wang J. Wu K.K. Jan Y.-J. Liou J.-Y. |
公開日期: | 2011 | 卷: | 58 | 期: | 5 | 起(迄)頁: | 705-711 | 來源出版物: | Histopathology | 摘要: | Aims: The results of our earlier studies suggested that 14-3-3ε is involved in cancer cell survival and growth. However, it is not clear whether 14-3-3ε plays a role in tumour metastasis and patient outcome. The aim of this study was to determine whether 14-3-3ε is a marker for predicting hepatocellular carcinoma (HCC) metastasis and survival. Methods and results: One hundred and fourteen patients with tissue-diagnosed primary HCC were followed for an average of 58.6months. 14-3-3ε in liver tissues was analysed by immunohistochemistry, and quantified by a Quick score system. Correlation of 14-3-3ε with patient survival and metastasis was analysed with a Wilcoxon signed rank test, Kaplan-Meier survival curves, and Cox proportional hazard regression. Seventy-one of 114 patients (62.3%) had a significant increase of 14-3-3ε expression in HCC tissues, whereas normal tissues expressed weak or undetectable 14-3-3ε. Elevated 14-3-3ε expression was significantly associated with shortened overall survival and progression-free survival. Furthermore, 14-3-3ε overexpression increased the risk of metastasis 4.6-fold. Conclusions: Overexpression of 14-3-3ε in primary HCC tissues predicts a high risk of extrahepatic metastasis and worse survival, and is a potential therapeutic target. ? 2011 Blackwell Publishing Limited. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562889 | ISSN: | 0309-0167 | DOI: | 10.1111/j.1365-2559.2011.03789.x | SDG/關鍵字: | protein 14 3 3; protein 14 3 3 epsilon; unclassified drug; adult; article; cancer survival; correlation analysis; female; human; human tissue; liver cell carcinoma; major clinical study; male; metastasis; overall survival; prediction; priority journal; progression free survival; protein expression; 14-3-3 Proteins; Carcinoma, Hepatocellular; Humans; Immunohistochemistry; Kaplan-Meier Estimate; Liver Neoplasms; Neoplasm Staging; Prognosis; Tumor Markers, Biological |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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