Severe isolated acute hepatic graft-versus-host disease with vanishing bile duct syndrome
Journal
Bone Marrow Transplantation
Journal Volume
14
Journal Issue
2
Pages
319-321
Date Issued
1994
Author(s)
Abstract
A 28-year-old man with chronic myelogenous leukaemia in blastic transformation underwent allogeneic bone marrow transplantation from his HLA-identical brother. Severe, progressive cholestatic jaundice developed from day 25 and did not respond to repeated therapy with high-dose methylprednisolone. In addition to marked cholestasis, both liver biopsy (day 69) and autopsy (day 134) findings revealed total disappearance of interlobular bile ducts in all of the portal areas, although extrahepatic manifestations of GVHD were minimal. Isolated acute vanishing bile duct syndrome can occur as the most severe form of acute hepatic GVHD.
SDGs
Other Subjects
azathioprine; busulfan; cyclophosphamide; cyclosporin a; methotrexate; methylprednisolone; ursodeoxycholic acid; adult; allogenic bone marrow transplantation; article; autopsy; bile duct disease; blast transformation; case report; chronic myeloid leukemia; graft versus host reaction; human; human tissue; intravenous drug administration; leukopenia; liver biopsy; liver disease; male; obstructive jaundice; oral drug administration; priority journal; Acute Disease; Adult; Bile Duct Diseases; Bone Marrow Transplantation; Case Report; Graft vs Host Disease; Human; Leukemia, Myeloid, Chronic; Liver Diseases; Male; Support, Non-U.S. Gov't; Transplantation, Homologous
Type
journal article