https://scholars.lib.ntu.edu.tw/handle/123456789/562994
標題: | Expression of P-glycoprotein and glutathione-S-transferase in recurrent lymphomas: The possible role of epstein-barr virus, immunophenotypes, and other predisposing factors | 作者: | ANN-LII CHENG Su I.-J. YAO-CHANG CHEN Lee T.-C. Wang C.-H. |
公開日期: | 1993 | 卷: | 11 | 期: | 1 | 起(迄)頁: | 109-115 | 來源出版物: | Journal of Clinical Oncology | 摘要: | Purpose: We previously have reported the poor prognoses of recurrent peripheral T-cell lymphoma (PTCL) and Epstein-Barr virus (EBV)-associated PTCL (J Clin Oncol 7:725-731, 1989; Blood 77:799-808, 1991). To study the role that drug resistance plays in this scenario, we conducted a retrospective study of 23 adult patients. Patients and Methods: All patients had recurrent lymphoma tissue available for immunophenotyping and screening for the existence of EBV DNA in tumor cells by Southern blot analysis and in situ hybridization. Expression of a multidrug resistance P-glycoprotein ([P-gp]mdr-1) and a glutathione redox cycle-related glutathione-S-transferase π (GST-π) was determined by an immunohistochemistry method. Results: Expression of mdr-1 or GST-π was found in 11 (48%) and 12 (52%) cases, respectively. Most (11 of 12) of the GST-π expression occurred simultaneously with mdr-1. Prechemotherapy tumor tissues were available in 11 cases; only two (18.2%) of these cases expressed mdr-1. Four (36%) of 11 cases that expressed mdr-1 (mdr-1 ( + )) and nine (90%) of 10 cases that did not ex-press mdr-1 (mdr-1( - )) responded to second-line chemotherapy (P < .05). The survival-after-recurrence (SAR) curves significantly favored mdr-1 ( - ) recurrent lymphoma(P < .05). The mdr-1 expression was further correlated with the immunophenotype and EBV association. All six cases of EBV-associated lymphoma (PTCL, five cases; Hodgkin's disease, one case) had significant simultaneous expression of mdr-1 and GST-π in their recurrent tumor tissues. Conclusion: (1) mdr-1 expression is a significant prognostic factor in recurrent lymphomas; (2) high expression of mdr-1 is observed in recurrent EBV-as-sociated PTCL; and (3) GST-π usually expresses simultaneously with mdr-1 in recurrent lymphomas. The role of EBV in the development of mdr-1 and the biologic significance of the simultaneous expression of mdr-1 and GST-T in recurrent lymphomas are well worth further exploration. ? 1993 by American Society of Clinical Oncology. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/562994 | ISSN: | 0732-183X | DOI: | 10.1200/JCO.1993.11.1.109 | SDG/關鍵字: | bleomycin; chlorambucil; cyclophosphamide; doxorubicin; etoposide; glutathione transferase; glycoprotein p; prednisolone; vincristine; virus dna; adult; article; cancer chemotherapy; cancer resistance; cancer survival; clinical article; disease predisposition; drug resistance; epstein barr virus; female; human; human tissue; immunophenotyping; lymphoma; male; priority journal; prognosis; recurrent cancer; Adolescent; Adult; Aged; Aged, 80 and over; Biological Markers; Child; DNA, Viral; Drug Resistance; Female; Glutathione Transferase; Herpesvirus 4, Human; Human; Immunophenotyping; Lymphoma; Male; Membrane Glycoproteins; Middle Age; Neoplasm Proteins; P-Glycoprotein; Recurrence; Retrospective Studies; Risk Factors; Support, Non-U.S. Gov't |
顯示於: | 醫學院附設醫院 (臺大醫院) |
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