https://scholars.lib.ntu.edu.tw/handle/123456789/563327
標題: | Bidens pilosa formulation improves blood homeostasis and β -cell function in men: A pilot study | 作者: | Lai B.-Y. Chen T.-Y. Huang S.-H. Kuo T.-F. Chang T.-H. CHIH-KANG CHIANG Yang M.-T. Chang C.L.-T. |
公開日期: | 2015 | 出版社: | Hindawi Limited | 卷: | 2015 | 來源出版物: | Evidence-based Complementary and Alternative Medicine | 摘要: | B. pilosa has long been purported to have antidiabetes activity, but despite the advancement in phytochemistry and animal models of diabetes, no human clinical trials have been conducted to date. Here, we evaluated the effect of a B. pilosa formulation on fasting blood glucose (FBG), fasting serum insulin, and glycosylated hemoglobin A1c (H b A 1 c) in diabetic subjects. The B. pilosa formulation reduced the level of FBG and H b A 1 c in diabetics but increased fasting serum insulin in healthy subjects. Moreover, combination of B. pilosa formulation with antidiabetic drugs had better glycemic control in diabetics. The homeostatic model assessment (HOMA) data suggested that the antidiabetic activity of this formulation was via improvement of β-cell function. We also tested the safety of the B. pilosa formulation in healthy subjects and observed no obvious side effects. We conclude that B. pilosa has potential as an antidiabetes treatment. ? 2015 Bun-Yueh Lai et al. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84926325282&doi=10.1155%2f2015%2f832314&partnerID=40&md5=9308d5e3ac0ec1758eab5eeba635c704 https://scholars.lib.ntu.edu.tw/handle/123456789/563327 |
ISSN: | 1741-427X | DOI: | 10.1155/2015/832314 | SDG/關鍵字: | antidiabetic agent; Bidens pilosa extract; hemoglobin A1c; absence of side effects; adult; aged; antidiabetic activity; Article; Bidens pilosa; cell function; clinical article; controlled study; drug effect; drug efficacy; drug formulation; drug mechanism; drug safety; glucose blood level; homeostasis; human; insulin blood level; male; non insulin dependent diabetes mellitus; pancreas islet beta cell; priority journal |
顯示於: | 毒理學研究所 |
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