https://scholars.lib.ntu.edu.tw/handle/123456789/563421
標題: | Design and synthesis of malonamide derivatives as antibiotics against methicillin-resistant staphylococcus aureus | 作者: | Su, J.-C. Huang, Y.-T. Chen, C.-S. HAO-CHIEH CHIU Shiau, C.-W. |
關鍵字: | Staphylococcus aureus; antibiotics; malonamide | 公開日期: | 一月-2018 | 卷: | 23 | 期: | 1 | 來源出版物: | Molecules | 摘要: | Methicillin-resistant Staphylococcus aureus (MRSA) is a serious threat to humans. Most existing antimicrobial drugs, including the β-lactam and quinoxiline classes, are not effective against MRSA. In this study, we synthesized 24 derivatives of malonamide, a new class of antibacterial agents and potentiators of classic antimicrobials. A derivative that increases bacterial killing and biofilm eradication with low cell toxicity was created. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/563421 | ISSN: | 1420-3049 | DOI: | 10.3390/molecules23010027 |
顯示於: | 醫學檢驗暨生物技術學系 |
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