https://scholars.lib.ntu.edu.tw/handle/123456789/563910
Title: | Neuronal aging: Learning from C. elegans | Authors: | C. H. Chen, Y. C. Chen, H. C. Jiang, C. K. Chen and C. L. Pan Chen Y.-C. Jiang H.-C. Chen C.-K. CHUN-HAO CHEN |
Issue Date: | 2013 | Publisher: | Ubiquity Press Ltd | Journal Volume: | 8 | Source: | Journal of Molecular Signaling | Abstract: | The heterogeneity and multigenetic nature of nervous system aging make modeling of it a formidable task in mammalian species. The powerful genetics, simple anatomy and short life span of the nematode Caenorhabditis elegans offer unique advantages in unraveling the molecular genetic network that regulates the integrity of neuronal structures and functions during aging. In this review, we first summarize recent breakthroughs in the morphological and functional characterization of C. elegans neuronal aging. Age-associated morphological changes include age-dependent neurite branching, axon beading or swelling, axon defasciculation, progressive distortion of the neuronal soma, and early decline in presynaptic release function. We then discuss genetic pathways that modulate the speed of neuronal aging concordant with alteration in life span, such as insulin signaling, as well as cell-autonomous factors that promote neuronal integrity during senescence, including membrane activity and JNK/MAPK signaling. As a robust genetic model for aging, insights from C. elegans neuronal aging studies will contribute to our mechanistic understanding of human brain aging. ? 2013 Chen et al.; licensee BioMed Central Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84889820930&doi=10.1186%2f1750-2187-8-14&partnerID=40&md5=77239d581a53e6cbcf6cfc796176546c https://scholars.lib.ntu.edu.tw/handle/123456789/563910 |
ISSN: | 1750-2187 | DOI: | 10.1186/1750-2187-8-14 | SDG/Keyword: | 4 aminobutyric acid receptor; Caenorhabditis elegans protein; heat shock transcription factor 1; insulin; mitogen activated protein kinase; potassium channel; somatomedin receptor; stress activated protein kinase; tau protein; transcription factor DAF 16; transcription factor FKHRL1; Alzheimer disease; Caenorhabditis elegans; cell aging; cytology; gene; genetic regulation; human; longevity; nerve cell; nerve fiber; neurite; nonhuman; priority journal; review; senescence; signal transduction; Caenorhabditis elegans; Mammalia |
Appears in Collections: | 毒理學研究所 |
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