|Title:||4-acetylantroquinonol B suppresses tumor growth and metastasis of hepatoma cells via blockade of translation-dependent signaling pathway and VEGF production||Authors:||Chang C.-H.
|Issue Date:||2015||Journal Volume:||63||Journal Issue:||1||Start page/Pages:||208-215||Source:||Journal of Agricultural and Food Chemistry||Abstract:||
Hepatocellular carcinoma (HCC) has become one of most common malignancies and a leading cause of cancer mortality worldwide. Previous study has shown that 4-acetylantroquinonol B (4AAQB) isolated from Antrodia cinnamomea (or niu-chang-chih) was observed to inhibit HepG2 cell proliferation via affecting cell cycle. However, the in vivo effects and antimetastatic activity of 4AAQB have not yet been addressed. This study found that 4AAQB inhibited HepG2 and HuH-7 hepatoma cell growth in both in vitro and in vivo models and exhibited pronounced inhibitory effects on HuH-7 tumor growth in xenograft and orthotopic models. 4AAQB efficiently inhibited the phosphorylation of mTOR and its upstream kinases and the downstream effectors and decreased the production of VEGF and activity of Rho GTPases in HuH-7 cells. Furthermore, 4AAQB inhibited in vitro HuH-7 cell migration and in vivo pulmonary metastasis. The results suggested that 4AAQB is a potential candidate for HCC therapy. ? 2014 American Chemical Society.
|URI:||https://scholars.lib.ntu.edu.tw/handle/123456789/564114||ISSN:||218561||DOI:||10.1021/jf504434v||SDG/Keyword:||Antibiotics; Cell proliferation; Cells; Cytology; Pathology; Tumors; 4AAQB; Antrodia cinnamomea; Hepatocellular carcinoma; metastasis; mTOR; RhoGTPase; VEGF; Cell signaling; Antrodia cinnamomea; 4-acetylantroquinonol B; antineoplastic agent; cyclohexanone derivative; gamma butyrolactone; mTOR protein, mouse; target of rapamycin kinase; vasculotropin A; analogs and derivatives; animal; Antrodia; Carcinoma, Hepatocellular; cell motion; cell proliferation; chemistry; down regulation; drug effects; genetics; HepG2 cell line; human; Liver Neoplasms; male; metabolism; metatarsal bone; nude mouse; pathology; pathophysiology; phosphorylation; protein synthesis; SCID mouse; signal transduction; 4-Butyrolactone; Animals; Antineoplastic Agents; Antrodia; Carcinoma, Hepatocellular; Cell Movement; Cell Proliferation; Cyclohexanones; Down-Regulation; Hep G2 Cells; Humans; Liver Neoplasms; Male; Metatarsal Bones; Mice, Nude; Mice, SCID; Phosphorylation; Protein Biosynthesis; Signal Transduction; TOR Serine-Threonine Kinases; Vascular Endothelial Growth Factor A
|Appears in Collections:||藥理學科所|
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