https://scholars.lib.ntu.edu.tw/handle/123456789/564808
標題: | Protopine, a novel microtubule-stabilizing agent, causes mitotic arrest and apoptotic cell death in human hormone-refractory prostate cancer cell lines | 作者: | Chen C.-H. Liao C.-H. Chang Y.-L. JIH-HWA GUH Pan S.-L. Teng C.-M. |
公開日期: | 2012 | 卷: | 315 | 期: | 1 | 起(迄)頁: | 1-11 | 來源出版物: | Cancer Letters | 摘要: | In this study, we investigated the anticancer effect of protopine on human hormone-refractory prostate cancer (HRPC) cells. Protopine exhibited an anti-proliferative effect by induction of tubulin polymerization and mitotic arrest, which ultimately led to apoptotic cell death. The data suggest that protopine increased the activity of cyclin-dependent kinase 1 (Cdk1)/cyclin B1 complex and that contributed to cell apoptosis by modulating mitochondria-mediated signaling pathways, such as Bcl-2 phosphorylation and Mcl-1 down-regulation. In conclusion, the data suggest that protopine is a novel microtubule stabilizer with anticancer activity in HRPC cells through apoptotic pathway by modulating Cdk1 activity and Bcl-2 family of proteins. ? 2011 Elsevier Ireland Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-81955167334&doi=10.1016%2fj.canlet.2011.09.042&partnerID=40&md5=e4094ad88f82febd0eca237b2e53a4ae https://scholars.lib.ntu.edu.tw/handle/123456789/564808 |
ISSN: | 3043835 | DOI: | 10.1016/j.canlet.2011.09.042 | SDG/關鍵字: | cyclin B1; cyclin dependent kinase 1; protein bcl 2; protein mcl 1; protopine; antineoplastic activity; apoptosis; article; cancer cell culture; cell cycle arrest; cell cycle G2 phase; cell cycle M phase; cell cycle progression; cell cycle regulation; cell proliferation; concentration response; controlled study; down regulation; drug cytotoxicity; drug structure; drug synthesis; enzyme activation; enzyme activity; human; human cell; in vitro study; intracellular signaling; microtubule assembly; mitochondrion; priority journal; prostate cancer; protein expression; protein phosphorylation; Apoptosis; Benzophenanthridines; Berberine Alkaloids; Cell Growth Processes; Cell Line, Tumor; Humans; Male; Mitosis; Neoplasms, Hormone-Dependent; Prostatic Neoplasms; Signal Transduction; Transfection; Tubulin Modulators |
顯示於: | 藥學系 |
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