New Prostanoids with Cytotoxic Activity from Taiwanese Octocoral Clavularia viridis
Journal
Journal of Natural Products
Journal Volume
67
Journal Issue
4
Pages
542-546
Date Issued
2004
Author(s)
Abstract
Bioassay-directed fractionation of the CH2Cl2-MeOH extract of Clavularia viridis collected in Taiwan has afforded seven new prostanoids, designated as 4-deacetoxyl-12-O-deacetylclavulone I (1), 4-deacetoxyl-12-O-deacetylclavulone II (2), bromovulone II (4), iodovulone II (5), 4-deacetoxyl-12-O-deacetylclavulone III (6), bromovulone III (7), and iodovulone III (8), in addition to seven known prostanoids (clavulones I, II, III 7-acetoxy-7,8-dihydroiodovulone, chlorovulones II, III and 4-deacetoxylclavulone II (3, claviridenone E)). The structures of compounds 1-8 were determined on the basis of 1D and 2D NMR techniques including COSY, HSQC, and HMBC experiments. Pharmacological study revealed that bromovulone III (7) and chlorovulone II exhibited the most promising cytotoxicity against human prostate (PC-3) and colon (HT29) cancer cells.
SDGs
Other Subjects
4 deaceoxylclavulone ii; 4 deacetoxyl 12 o deacetylclavulone i; 4 deacetoxyl 12 o deacetylclavulone ii; 4 deacetoxyl 12 o deacetylclavulone iii; 7 acetoxy 7,8 dihydroiodovulone; bromovulone ii; bromovulone iii; chlorovulone ii; chlorovulone iii; claviridenone b; claviridenone c; claviridenone d; iodovulone ii; iodovulone iii; prostanoid; unclassified drug; article; bioassay; cancer cell; clavularia viridis; colon cancer; cytotoxicity; drug structure; fractionation; human; human cell; medicinal plant; prostate cancer; Taiwan; Animals; Anthozoa; Antineoplastic Agents; Colonic Neoplasms; Drug Screening Assays, Antitumor; Humans; Male; Molecular Structure; Nuclear Magnetic Resonance, Biomolecular; Oceans and Seas; Prostaglandins; Prostatic Neoplasms; Taiwan; Tumor Cells, Cultured; Clavularia; Clavularia viridis
Type
journal article