The regulation of drug-metabolizing enzymes and membrane transporters by inflammation: Evidences in inflammatory diseases and age-related disorders
Journal
Journal of Food and Drug Analysis
Journal Volume
27
Journal Issue
1
Pages
48-59
Date Issued
2019
Author(s)
Wu K.-C.
Abstract
Drug-metabolizing enzymes (DMEs) and membrane transporters play important roles in the absorption, distribution, metabolism, and excretion processes that determine the pharmacokinetics of drugs. Inflammation has been shown to regulate the expression and function of these drug-processing proteins. Given that inflammation is a common feature of many diseases, in this review, the general mechanisms for inflammation-mediated regulation of DMEs and transporters are described. Also, evidences regarding the aberrant expression of these drug-processing proteins in several inflammatory diseases and age-related disorders are provided. ? 2018
Subjects
Drug-metabolizing enzyme; Inflammation; Membrane transporter; Pharmacokinetics
SDGs
Other Subjects
cell nucleus receptor; cytokine; drug metabolizing enzyme; immunoglobulin enhancer binding protein; carrier protein; drug; aging; degenerative disease; enzyme regulation; gene control; human; inflammation; inflammatory bowel disease; inflammatory disease; insulin dependent diabetes mellitus; metabolic disorder; nonhuman; protein expression; protein function; Review; rheumatoid arthritis; age; animal; enzymology; genetics; inflammation; metabolism; pharmacokinetics; Age Factors; Animals; Inflammation; Membrane Transport Proteins; Pharmaceutical Preparations; Pharmacokinetics
Type
review