https://scholars.lib.ntu.edu.tw/handle/123456789/565238
標題: | Plasma metabolomic profiles predict near-term death among individuals with lower extremity peripheral arterial disease | 作者: | Huang C.-C. McDermott M.M. Liu K. CHING-HUA KUO Wang S.-Y. Tao H. YUFENG JANE TSENG |
公開日期: | 2013 | 卷: | 58 | 期: | 4 | 起(迄)頁: | 989-996.e1 | 來源出版物: | Journal of Vascular Surgery | 摘要: | Background: Individuals with peripheral arterial disease (PAD) have a nearly two-fold increased risk of all-cause and cardiovascular disease mortality compared to those without PAD. This pilot study determined whether metabolomic profiling can accurately identify patients with PAD who are at increased risk of near-term mortality. Methods: We completed a case-control study using 1H NMR metabolomic profiling of plasma from 20 decedents with PAD, without critical limb ischemia, who had blood drawn within 8 months prior to death (index blood draw) and within 10 to 28 months prior to death (preindex blood draw). Twenty-one PAD participants who survived more than 30 months after their index blood draw served as a control population. Results: Results showed distinct metabolomic patterns between preindex decedent, index decedent, and survivor samples. The major chemical signals contributing to the differential pattern (between survivors and decedents) arose from the fatty acyl chain protons of lipoproteins and the choline head group protons of phospholipids. Using the top 40 chemical signals for which the intensity was most distinct between survivor and preindex decedent samples, classification models predicted near-term all-cause death with overall accuracy of 78% (32/41), a sensitivity of 85% (17/20), and a specificity of 71% (15/21). When comparing survivor with index decedent samples, the overall classification accuracy was optimal at 83% (34/41) with a sensitivity of 80% (16/20) and a specificity of 86% (18/21), using as few as the top 10 to 20 chemical signals. Conclusions: Our results suggest that metabolomic profiling of plasma may be useful for identifying PAD patients at increased risk for near-term death. Larger studies using more sensitive metabolomic techniques are needed to identify specific metabolic pathways associated with increased risk of near-term all-cause mortality among PAD patients.? 2013 by the Society for Vascular Surgery. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84884910285&doi=10.1016%2fj.jvs.2013.04.022&partnerID=40&md5=6c2acb590074f7a8ed99d08a3a81ad06 https://scholars.lib.ntu.edu.tw/handle/123456789/565238 |
ISSN: | 7415214 | DOI: | 10.1016/j.jvs.2013.04.022 | SDG/關鍵字: | choline; lipoprotein; phospholipid; aged; article; cardiovascular mortality; case control study; cause of death; clinical article; controlled study; female; human; male; metabolomics; peripheral occlusive artery disease; pilot study; priority journal; proton nuclear magnetic resonance; risk assessment; sensitivity and specificity |
顯示於: | 藥學系 |
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