https://scholars.lib.ntu.edu.tw/handle/123456789/566069
標題: | Adzuki Bean Water Extract Attenuates Obesity by Modulating M2/M1 Macrophage Polarization and Gut Microbiota Composition | 作者: | Lee, P.-S. Teng, C.-Y. Hsieh, K.-F. Chiou, Y.-S. Wu, J.-C. Lu, T.-J. Pan, M.-H. MIN-HSIUNG PAN TING-JANG LU |
關鍵字: | adipose tissue macrophages; adzuki beans; gut microbiota; obesity; Wnt/β-catenin pathway | 公開日期: | 2019 | 卷: | 63 | 期: | 23 | 來源出版物: | Molecular Nutrition and Food Research | 摘要: | Scope: Obesity is a chronic condition resulting in excessive fat accumulation in adipose tissues. Adipose tissue is now considered as an immune organ, at the crossroads between metabolism and immunity. Thus, this study investigates the effects of adzuki beans on obesity and gut microbiota in high fat diet-induced mice. Methods and results: In this study, adzuki bean hot water extract (AWE) is determined to have the most significant anti-adipogenic effect; it is able to inhibit lipid accumulation in 3T3-L1 adipocytes and reduces body weight and adipose tissue weight in a dose-dependent manner. AWE treatment also decreases M1-polarized adipose tissue macrophages (ATMs) while inducing M2-polarized ATMs. The number and size of fat vacuoles in liver lesions are significantly reduced, indicating that AWE could ameliorate steatosis in high fat diet-induced mice. The results also demonstrate that AWE-treated groups inhibit adipogenesis via activating the Wnt/β-catenin pathway and reduce peroxisome proliferator-activated receptor gamma and CCAAT/enhancer binding proteins α expression. Moreover, the studies confirm that AWE decreases obesity through modulating gut microbiota. Conclusion: The results demonstrate that AWE supplementation ameliorates high fat diet-induced obesity and gut microbiota composition and suggests that AWE may have the potential to be developed into a functional food to improve metabolic disorders. ? 2019 WILEY-VCH Verlag GmbH & Co. KGaA, Weinheim |
URI: | https://www.scopus.com/inward/record.url?eid=2-s2.0-85074019210&partnerID=40&md5=e9c66d7135227bf8dd939e58d0938e98 https://scholars.lib.ntu.edu.tw/handle/123456789/566069 |
DOI: | 10.1002/mnfr.201900626 | SDG/關鍵字: | antiobesity agent; lipid; plant extract; 3T3-L1 cell line; adipogenesis; animal; blood; C57BL mouse; cell polarity; drug effect; intestine flora; lipid diet; lipid metabolism; macrophage; male; mouse; physiology; Vigna; Wnt signaling; 3T3-L1 Cells; Adipogenesis; Animals; Anti-Obesity Agents; Cell Polarity; Diet, High-Fat; Gastrointestinal Microbiome; Lipid Metabolism; Lipids; Macrophages; Male; Mice; Mice, Inbred C57BL; Plant Extracts; Vigna; Wnt Signaling Pathway |
顯示於: | 食品科技研究所 |
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