Infections of cefotaxime-resistant and cefmetazole-susceptible Escherichia coli and Klebsiella pneumoniae in children
Journal
Journal of Microbiology, Immunology and Infection
Journal Volume
38
Journal Issue
2
Pages
112-116
Date Issued
2005
Author(s)
Wu T.-Z.
Wang C.-Y.
Yang C.-Y.
Abstract
A search of the computerized database at the National Taiwan University Hospital was made for cefotaxime-resistant and cefmetazole-susceptible isolates of Escherichia coli and Klebsiella pneumoniae (which may be extended-spectrum β-lactamase-producing strains) in pediatric wards and intensive care units between 1999 and 2001. Fourteen infectious episodes attributed only to study bacteria were identified, including 7 episodes of bacteremia. Nine patients (64.3%) had underlying medical conditions: 3 were premature babies, 3 were immunodeficient, 2 had malignancy, and 2 had a congenital heart disease with active heart failure even after surgery. Among the 7 patients with bacteremias, 5 may be catheter-related; 6 were treated with carbapenems and 1 was treated with cefmetazole successfully, with or without the removal of the catheter. Before the acquisition of the infection, a history of stay in an intensive care unit within 4 weeks was noted in 10 cases (71.4%); a history of use of extended-spectrum cephalosporins within 4 weeks was also noted in 6 cases (42.9%). Cefmetazole, with or without an aminoglycoside, was clinically effective in 6 cases (42.8%). Except for 1 episode of pneumonia that ended in mortality, all of the infectious episodes were successfully treated. The mortality rate was 7.1%.
SDGs
Other Subjects
amikacin; aminoglycoside antibiotic agent; carbapenem derivative; cefmetazole; cefotaxime; ceftazidime; cephalosporin derivative; corticotropin; gentamicin; imipenem; meropenem; adolescent; antibiotic resistance; antibiotic sensitivity; article; bacteremia; bacterium isolate; catheter infection; child; childhood mortality; clinical article; congenital heart disease; data base; drug efficacy; Escherichia coli; female; Gram negative infection; heart failure; human; immune deficiency; infant; infantile spasm; intensive care unit; Klebsiella pneumoniae; male; malignant neoplastic disease; nonhuman; pneumonia; prematurity; Taiwan; Adolescent; Anti-Bacterial Agents; Bacteremia; Carbapenems; Catheterization; Cefmetazole; Cefotaxime; Child; Child, Preschool; Drug Resistance, Bacterial; Escherichia coli; Escherichia coli Infections; Female; Heart Defects, Congenital; Humans; Immunologic Deficiency Syndromes; Infant; Inpatients; Klebsiella Infections; Klebsiella pneumoniae; Male; Neoplasms; Premature Birth; Taiwan
Type
journal article