https://scholars.lib.ntu.edu.tw/handle/123456789/566666
標題: | Empirical monotherapy with meropenem in serious bacterial infections in children | 作者: | Hsu H.-L. CHUN-YI LU Tseng H.-Y. PING-ING LEE Lai H.-P. Lin W.-C. Hsieh Y.-C. CHIN-YUN LEE LI-MIN HUANG |
公開日期: | 2001 | 卷: | 34 | 期: | 4 | 起(迄)頁: | 275-280 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | The efficacy and safety profile of meropenem were analyzed according to data collected from hospitalized pediatric patients aged 4 days to 20 years who had serious bacterial infections and were treated in a major teaching hospital in Taipei. Of the 53 patients enrolled, 47 were analyzed for clinical efficacy and 53 for safety. The satisfactory clinical response rate was 57% in lower respiratory tract infection, 58% in septicemia, 100% in complicated urinary tract infection, osteomyelitis, and central nervous system infection, 83% in skin and soft tissue infection, and 93% in intra-abdominal infection. Eleven (21%) patients experienced adverse events related to meropenem. The most commonly observed adverse reactions were elevated hepatic enzymes (7.5%), increased alkaline phosphatase (3.8%), and thrombocytosis (3.8%). There was no meropenem-related seizure, withdrawal, or death. The results of this study suggested that meropenem is well tolerated even in young infants, and is effective in treating serious childhood bacterial infection. However, this study also identified a proportion of hospitalized pediatric patients with isolates that were resistant to meropenem. The trends in meropenem resistance among nosocomially acquired bacteria should be monitored closely. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-0035682355&partnerID=40&md5=51ef175e24b6cb9dba5a54811fef1e6d https://scholars.lib.ntu.edu.tw/handle/123456789/566666 |
ISSN: | 0253-2662 | SDG/關鍵字: | alkaline phosphatase; liver enzyme; meropenem; abdominal infection; adolescent; adult; antibiotic resistance; antibiotic therapy; article; bacterial infection; bacterium isolate; central nervous system infection; child; clinical article; drug efficacy; drug safety; drug tolerability; female; hospital infection; human; infant; liver toxicity; lower respiratory tract infection; male; mortality; newborn; osteomyelitis; septicemia; skin infection; soft tissue infection; superinfection; thrombocytosis; treatment outcome; urinary tract infection; Adult; Bacterial Infections; Child; Drug Evaluation; Female; Humans; Infant, Newborn; Male; Prospective Studies; Respiratory Tract Infections; Sepsis; Thienamycins; Treatment Outcome |
顯示於: | 醫學系 |
在 IR 系統中的文件,除了特別指名其著作權條款之外,均受到著作權保護,並且保留所有的權利。