|Title:||Acute respiratory distress syndrome due to tuberculosis in a child after allogeneic bone marrow transplantation for acute lymphoblastic leukemia||Authors:||Chen C.-C.
|Issue Date:||1999||Journal Volume:||98||Journal Issue:||10||Start page/Pages:||701-704||Source:||Journal of the Formosan Medical Association||Abstract:||
We report the occurrence of tuberculosis in a 10-year-old Taiwanese boy, approximately 4 months after he received a matched-related bone marrow transplantation from his sister for acute T-cell lymphoblastic leukemia. After transplantation, grade III acute graft-versus-host disease developed and the patient was treated with prednisolone and cyclosporine. Marrow failure was noted on day 77 post-transplantation, however, after an episode of herpes zoster infection. Interstitial pneumonia, diagnosed on the basis of chest x-ray and computed tomography findings, occurred on day 120. Histologic examination of an open-lung biopsy specimen showed caseating granulomas and a few acid-fast bacilli. The patient died of acute respiratory distress syndrome, despite immediate implementation of anti-tuberculosis therapy. Sputum cultures grew Mycobacterium tuberculosis 5 weeks later. This report demonstrates that the possibility of tuberculosis needs to be considered in immunocompromised patients, and that appropriate prophylaxis should be instituted in areas where tuberculosis is endemic.
|ISSN:||0929-6646||SDG/Keyword:||aciclovir; cyclosporin; isoniazid; methylprednisolone; prednisolone; pyrazinamide; rifampicin; tuberculostatic agent; acute lymphoblastic leukemia; allogenic bone marrow transplantation; article; case report; child; computer assisted tomography; graft versus host reaction; herpes zoster; human; interstitial pneumonia; male; mycobacterium tuberculosis; open lung biopsy; respiratory distress syndrome; sputum culture; thorax radiography; tuberculosis; Bone Marrow Transplantation; Child; Humans; Leukemia, Lymphocytic, Acute, L1; Male; Respiratory Distress Syndrome, Adult; Tuberculosis, Pulmonary
|Appears in Collections:||醫學系|
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