https://scholars.lib.ntu.edu.tw/handle/123456789/567245
標題: | Diabetic polyneuropathy and the risk of developing diabetic retinopathy: A nationwide, population-based study | 作者: | Lin I.-C. Wang Y.-H. Lin C.-L. Chang Y.-J. Lee S.-H. I-JONG WANG |
關鍵字: | diabetic polyneuropathy; diabetic retinopathy; population-based studies | 公開日期: | 2015 | 出版社: | Blackwell Publishing Ltd | 卷: | 93 | 期: | 8 | 起(迄)頁: | 713-718 | 來源出版物: | Acta Ophthalmologica | 摘要: | Purpose To assess the relationship between diabetic polyneuropathy (DPN) and the risk of diabetic retinopathy (DR). Methods From 1997 to 2010, we identified 5031 newly diagnosed DPN patients and 20 124 controls matched for sex, age, and index year. Cox proportional hazards regression analyses were used to estimate the adjusted hazard ratios (HRs) and 95% confidence intervals (CIs) of DR between the DPN patients and the non-DPN group. The adjusted hazard ratio was calculated and adjusted for age, sex, duration of diabetes and comorbidities of hypertension, cardiovascular disease and diabetic nephropathy. Results The incidence rate of DR was 5.87-fold higher in the DPN patients than in the non-DPN group (44.0 vs. 7.22 per 1000 person-years), with an adjusted HR of 5.41(95% CI = 4.92-5.94). The DPN-to-non-DPN DR incidence rate ratio decreased with age (adjusted HR = 6.63 for subgroup younger than 65 years and adjusted HR = 3.91 for subgroup aged 65 years or older). Compared with the non-DPN group, the DPN patients had a 5.63-fold risk of non-proliferative DR (adjusted HR = 5.63, 95% CI = 5.11-6.21) and a 3.67-fold risk of proliferative DR (adjusted HR = 3.67, 95% CI = 2.57-5.23). Conclusion The patients with DPN had an increased risk of developing DR and advanced DR compared with the non-DPN group, particularly among the subgroup aged younger than 65 years. ? 2015 Acta Ophthalmologica Scandinavica Foundation. Published by John Wiley & Sons Ltd. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84955649426&doi=10.1111%2faos.12746&partnerID=40&md5=a6503209a2b7907ef845c2bd70cc8fbd https://scholars.lib.ntu.edu.tw/handle/123456789/567245 |
ISSN: | 1755-375X | DOI: | 10.1111/aos.12746 | SDG/關鍵字: | adult; age; aged; Article; cardiovascular disease; cohort analysis; comorbidity; controlled study; diabetic nephropathy; diabetic neuropathy; diabetic retinopathy; disease association; female; hazard ratio; human; hypertension; incidence; major clinical study; male; population research; priority journal; proliferative diabetic retinopathy; proportional hazards model; retrospective study; Diabetic Neuropathies; diabetic retinopathy; middle aged; public health; risk factor; statistics and numerical data; Taiwan; Aged; Diabetic Neuropathies; Diabetic Retinopathy; Female; Humans; Incidence; Male; Middle Aged; National Health Programs; Proportional Hazards Models; Retrospective Studies; Risk Factors; Taiwan |
顯示於: | 醫學系 |
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