https://scholars.lib.ntu.edu.tw/handle/123456789/567278
標題: | Ethambutol-induced optic neuropathy: A nationwide population-based study from Taiwan | 作者: | Chen H.-Y. Lai S.-W. Muo C.-H. Chen P.-C. I-JONG WANG |
公開日期: | 2012 | 卷: | 96 | 期: | 11 | 起(迄)頁: | 1368-1371 | 來源出版物: | British Journal of Ophthalmology | 摘要: | Aim: To investigate the risk factors and comorbidities associated with ethambutol-induced optic neuropathy (EON). Method: Using the Taiwan Longitudinal Health Insurance Database, we conducted a study within a nationwide representative cohort of patients treated with EMB. We identified 231 patients newly diagnosed with EON between 2000 and 2008, and 924 control subjects. Adjusted OR by estimating the risk of EON in relation to comorbidities and EMB prescription protocol was determined. Results: Compared with the control group, EON patients were at risk with older age, hypertension (adjusted OR=1.62, 95% CI 1.16 to 2.26) and renal diseases (without end-stage renal diseases (ESRD), adjusted OR=2.11, 95% CI 1.02 to 4.35; with ESRD, adjusted OR=3.73, 95% CI 1.79 to 7.74). Patients with an EMB prescription duration longer than 3 months were not at elevated risk compared with those whose prescription less than 3 months (OR=1.35, 95% CI 0.99 to 1.83, adjusted for age, sex, hypertension and renal diseases). Patients whose average daily dose was greater than 1200 mg, compared with the other two groups (800?1199 mg, less than 800 mg) were not at increased risk for EON. Conclusions: Age, hypertension and renal diseases are risk factors for EON in the Taiwanese population. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84868130410&doi=10.1136%2fbjophthalmol-2012-301870&partnerID=40&md5=40145a3f4131d404fe931337ebff2824 https://scholars.lib.ntu.edu.tw/handle/123456789/567278 |
ISSN: | 0007-1161 | DOI: | 10.1136/bjophthalmol-2012-301870 | SDG/關鍵字: | ethambutol; adult; age; aged; alcoholism; article; clinical protocol; cohort analysis; comorbidity; controlled study; diabetes mellitus; disease association; drug induced disease; ethambutol induced optic neuropathy; female; gallstone; health program; hepatitis B; hepatitis C; human; hypertension; hypertriglyceridemia; incidence; kidney disease; kidney failure; major clinical study; male; malignant neoplastic disease; obesity; optic nerve disease; palindromic rheumatism; polyarthritis; population research; prescription; priority journal; Reiter syndrome; rheumatic disease; rheumatic polymyalgia; rheumatoid arthritis; risk factor; risk reduction; sex; systemic lupus erythematosus; Taiwan; treatment duration; Adult; Aged; Antitubercular Agents; Ethambutol; Female; Follow-Up Studies; Humans; Incidence; Male; Middle Aged; Optic Nerve Diseases; Population Surveillance; Retrospective Studies; Risk Factors; Taiwan; Tuberculosis; Young Adult |
顯示於: | 醫學系 |
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