https://scholars.lib.ntu.edu.tw/handle/123456789/567387
標題: | Applications of the Chick Chorioallantoic Membrane as an Alternative Model for Cancer Studies | 作者: | Chu P.-Y. Koh A.P.-F. Antony J. RUBY YUN-JU HUANG |
公開日期: | 2022 | 出版社: | S. Karger AG | 來源出版物: | Cells Tissues Organs | 摘要: | A variety of in vivo experimental models have been established for the studies of human cancer using both cancer cell lines and patient-derived xenografts (PDXs). In order to meet the aspiration of precision medicine, the in vivomurine models have been widely adopted. However, common constraints such as high cost, long duration of experiments, and low engraftment efficiency remained to be resolved. The chick embryo chorioallantoic membrane (CAM) is an alternative model to overcome some of these limitations. Here, we provide an overview of the applications of the chick CAM model in the study of oncology. The CAM model has shown significant retention of tumor heterogeneity alongside increased xenograft take rates in several PDX studies. Various imaging techniques and data analysis have been applied to study tumor metastasis, angiogenesis, and therapeutic response to novel agents. Lastly, to practically illustrate the feasibility of utilizing the CAM model, we summarize the general protocol used in a case study utilizing an ovarian cancer PDX. ? 2021 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85103544394&doi=10.1159%2f000513039&partnerID=40&md5=6d4e6648925e750aa465f4227fba95f5 https://scholars.lib.ntu.edu.tw/handle/123456789/567387 |
ISSN: | 1422-6405 | DOI: | 10.1159/000513039 |
顯示於: | 醫學系 |
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