https://scholars.lib.ntu.edu.tw/handle/123456789/567495
標題: | Vascular hypoperfusion in acute optic neuritis is a potentially new neurovascular model for demyelinating diseases | 作者: | TA-CHING CHEN Yeh C.-Y. CHAO-WEN LIN CHUNG-MAY YANG CHANG-HAO YANG Lin I.-H. Chen P.-Y. Cheng J.-Y. FUNG-RONG HU |
公開日期: | 2017 | 出版社: | Public Library of Science | 卷: | 12 | 期: | 9 | 起(迄)頁: | e0184927 | 來源出版物: | PLoS ONE | 摘要: | Purpose: Optic neuritis is highly correlated with multiple sclerosis and is a major cause of acute visual loss and long-term neuronal degeneration. Primary cerebral hypoperfusion has been reported in brain demyelinating diseases. This study investigated whether peripapillary perfusion is changed in patients with acute optic neuritis (AON). Methods: This three-year cohort study was conducted from September 1 2012, to August 31, 2015. Two hundred and forty-one patients with non-glaucomatous acute optic neuropathy were screened, and 42 non-highly myopic patients who had suffered their first episode of unilaterally idiopathic AON were studied. All cases received spectral-domain optical coherence tomography (OCT) examination, general survey, and standard corticosteroid therapy. OCT images were analyzed using a customized MATLAB program for measuring peripapillary choroidal thickness (PCT). Multivariate regression models were constructed to identify factors that are significantly related to peripapillary perfusion. Results: Decreased PCT was found in eyes experiencing AON combined with disc swelling (the ratio of lesion eye PCT/fellow eye PCT was 0.87 ± 0.08; range, from 0.75 to 1.00). In comparison to the healthy fellow eyes, approximately every 26% increase in the thickness of the retinal nerve fiber layer due to axonal swelling was associated with a 10% decreased thickness of PCT. Thinner PCT is also correlated with poorer trough vision, which may lead to poorer final vision. These findings were obvious in patients with optic papillitis but not in patients with retrobulbar neuritis. Conclusions: Peripapillary vascular hypoperfusion was found in patients experiencing AON combined with disc swelling. These findings are unlike those for other ocular inflammatory diseases but are consistent with cerebral hypoperfusion, which is found in brain demyelinating diseases; thus, these findings may represent a new neurovascular model in this field. ? 2017 Chen et al. This is an open access article distributed under the terms of the Creative Commons Attribution License, which permits unrestricted use, distribution, and reproduction in any medium, provided the original author and source are credited. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-85029803953&doi=10.1371%2fjournal.pone.0184927&partnerID=40&md5=806f5b493b6012fd7d2236289a454432 https://scholars.lib.ntu.edu.tw/handle/123456789/567495 |
ISSN: | 1932-6203 | DOI: | 10.1371/journal.pone.0184927 | SDG/關鍵字: | adult; Article; choroidal thickness; cohort analysis; color vision; corticosteroid therapy; demyelinating disease; disease association; disease duration; eye movement; eye pain; female; human; major clinical study; male; optic nerve; optic neuritis; optical coherence tomography; papillitis; perfusion; retinal nerve fiber layer thickness; retrobulbar optic neuropathy; vascular disease; vascular hypoperfusion; visual acuity; visual field defect; acute disease; biological model; choroid; demyelinating disease; diagnostic imaging; metabolism; middle aged; optic neuritis; papilledema; pathology; physiology; regression analysis; retina; young adult; corticosteroid; Acute Disease; Adrenal Cortex Hormones; Adult; Choroid; Cohort Studies; Demyelinating Diseases; Female; Humans; Male; Middle Aged; Models, Biological; Optic Neuritis; Papilledema; Regression Analysis; Retina; Tomography, Optical Coherence; Young Adult |
顯示於: | 醫學系 |
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