https://scholars.lib.ntu.edu.tw/handle/123456789/567508
標題: | The combined effect of IL-4 and IL-10 suppresses the generation of, but does not change the polarity of, type-1 T cells in Histoplasma infection | 作者: | Peng, Jung-Kuei JR-SHIUAN LIN Kung, John T Finkelman, Fred D BETTY AN-YE WU-HSIEH |
關鍵字: | Histoplasmosis | IFN-γ-producing cells | T cell polarity | Type-1 and type-2 cytokines | 公開日期: | 二月-2005 | 卷: | 17 | 期: | 2 | 來源出版物: | International immunology | 摘要: | Dominant type-1 cytokine production is induced in a murine model of systemic histoplasmosis. We used this model to investigate whether the presence of antagonistic cytokines during T cell priming changes the polarity of T cells in response to Histoplasma infection. Before infection with Histoplasma capsulatum, mice were injected twice with goat anti-mouse IgD antiserum (GalphaMdelta), which induced expression of dominant type-2 cytokines. At days 7 and 14 after infection, the GalphaMdelta-treated mice had suppressed IFN-gamma response and a significantly greater fungal burden in their spleens and lungs. The number of IFN-gamma-producing cells as well as the level of IFN-gamma produced per cell was greatly reduced. Not only CD4+ T cells but also CD8+ T cells were affected. The number of Histoplasma-induced IFN-gamma-producing cells was partially restored in GalphaMdelta-treated IL-4-/- and IL-10-/- mice and completely restored in IL-4-/- IL-10-/- mice. Thus, the combined effect of IL-4 and IL-10 suppressed the generation of IFN-gamma-producing cells. A longitudinal study demonstrated that as IL-4 and IL-10 decreased, the number of Histoplasma-induced IFN-gamma-producing cells rapidly increased, and fungal clearance improved, demonstrating that the presence of IL-4 and IL-10 did not permanently change the polarity of T cells. |
URI: | https://scholars.lib.ntu.edu.tw/handle/123456789/567508 | ISSN: | 0953-8178 | DOI: | 10.1093/intimm/dxh200 |
顯示於: | 免疫學研究所 |
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