https://scholars.lib.ntu.edu.tw/handle/123456789/567595
標題: | Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus-infected carriers: A prospective study in Taiwan | 作者: | CHI-LING CHEN WEI-SHIUNG YANG Yang H.-I. Chen C.-F. You S.-L. Wang L.-Y. Lu S.-N. CHUN-JEN LIU JIA-HORNG KAO PEI-JER CHEN DING-SHINN CHEN Chen C.-J. |
公開日期: | 2014 | 出版社: | American Association for Cancer Research Inc. | 卷: | 23 | 期: | 8 | 起(迄)頁: | 1659-1671 | 來源出版物: | Cancer Epidemiology Biomarkers and Prevention | 摘要: | Background: Obesity is considered a risk factor for hepatocellular carcinoma (HCC). The relationship between adipocytokine and HCC in hepatitis B virus (HBV) carriers remains unclear. We prospectively investigated the association of adiponectin, leptin, and visfatin levels with HCC Methods: We conducted a nested case-control study in a community-based cohort with 187 incident HCC and 374 HCC-free HBV carriers. Unconditional logistic regression was conducted to estimate the ORs and 95% confidence intervals (CI). Results: Adiponectin, but not leptin and visfatin, levels were associated with an increased risk of HCC after adjustment for other metabolic factors and HBV-related factors. The risk was increased [OR = 0.51; 95% CI, 0.12-2.11; OR = 4.88 (1.46-16.3); OR = 3.79 (1.10-13.0); OR = 4.13 (1.13-15.1) with each additional quintiles, respectively] with a significant dose-response trend (Ptrend = 0.003). HCC risk associated with higher adiponectin level was higher in HBV carriers with ultrasonographic fatty liver, genotype C infection, higher viral load, and with elevated alanine aminotransferase. Longitudinally, participants with higher adiponectin were less likely to achieve surface antigen of hepatitis B virus (HBsAg) seroclearance and more likely to have persistently higher HBV DNA. Eventually, they were more likely to develop liver cirrhosis [OR = 1.65 (0.62-4.39); OR = 3.85 (1.47-10.1); OR = 2.56 (0.96-6.84); OR = 3.76 (1.33-10.7) for the second, third, fourth, and fifth quintiles, respectively; Ptrend = 0.017] before HCC Conclusions: Elevated adiponectin levels were independently associated with an increased risk of HCC Impact: Adiponectin may play different roles in the virus-induced and metabolic-related liver diseases, but the underlying mechanism remains unknown. ? 2014 American Association for Cancer Research. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84905446129&doi=10.1158%2f1055-9965.EPI-14-0161&partnerID=40&md5=8383a9e9538e6c61b36ba126dd094e50 https://scholars.lib.ntu.edu.tw/handle/123456789/567595 |
ISSN: | 1055-9965 | DOI: | 10.1158/1055-9965.EPI-14-0161 | SDG/關鍵字: | adiponectin; alanine aminotransferase; aspartate aminotransferase; cholesterol; hepatitis B surface antigen; leptin; nicotinamide phosphoribosyltransferase; triacylglycerol; virus DNA; adipocytokine; adiponectin; cytokine; leptin; nicotinamide phosphoribosyltransferase; nicotinamide phosphoribosyltransferase, human; adult; aged; alanine aminotransferase blood level; alcohol consumption; article; aspartate aminotransferase blood level; betel nut; cancer risk; case control study; cholesterol blood level; controlled study; diabetes mellitus; disease association; fatty liver; female; genotype; hepatitis B; Hepatitis B virus; human; human tissue; hypertension; liver cell carcinoma; liver cirrhosis; major clinical study; male; priority journal; prospective study; protein blood level; smoking; Taiwan; triacylglycerol blood level; virus load; waist circumference; waist hip ratio; blood; Carcinoma, Hepatocellular; complication; hepatitis B; incidence; Liver Neoplasms; middle aged; risk factor; virology; Adipokines; Adiponectin; Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Cytokines; Female; Hepatitis B, Chronic; Humans; Incidence; Leptin; Liver Neoplasms; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Risk Factors |
顯示於: | 醫學系 |
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