Plasma adipokines and risk of hepatocellular carcinoma in chronic hepatitis B virus-infected carriers: A prospective study in Taiwan
Journal
Cancer Epidemiology Biomarkers and Prevention
Journal Volume
23
Journal Issue
8
Pages
1659-1671
Date Issued
2014
Author(s)
Yang H.-I.
Chen C.-F.
You S.-L.
Wang L.-Y.
Lu S.-N.
Chen C.-J.
Abstract
Background: Obesity is considered a risk factor for hepatocellular carcinoma (HCC). The relationship between adipocytokine and HCC in hepatitis B virus (HBV) carriers remains unclear. We prospectively investigated the association of adiponectin, leptin, and visfatin levels with HCC Methods: We conducted a nested case-control study in a community-based cohort with 187 incident HCC and 374 HCC-free HBV carriers. Unconditional logistic regression was conducted to estimate the ORs and 95% confidence intervals (CI). Results: Adiponectin, but not leptin and visfatin, levels were associated with an increased risk of HCC after adjustment for other metabolic factors and HBV-related factors. The risk was increased [OR = 0.51; 95% CI, 0.12-2.11; OR = 4.88 (1.46-16.3); OR = 3.79 (1.10-13.0); OR = 4.13 (1.13-15.1) with each additional quintiles, respectively] with a significant dose-response trend (Ptrend = 0.003). HCC risk associated with higher adiponectin level was higher in HBV carriers with ultrasonographic fatty liver, genotype C infection, higher viral load, and with elevated alanine aminotransferase. Longitudinally, participants with higher adiponectin were less likely to achieve surface antigen of hepatitis B virus (HBsAg) seroclearance and more likely to have persistently higher HBV DNA. Eventually, they were more likely to develop liver cirrhosis [OR = 1.65 (0.62-4.39); OR = 3.85 (1.47-10.1); OR = 2.56 (0.96-6.84); OR = 3.76 (1.33-10.7) for the second, third, fourth, and fifth quintiles, respectively; Ptrend = 0.017] before HCC Conclusions: Elevated adiponectin levels were independently associated with an increased risk of HCC Impact: Adiponectin may play different roles in the virus-induced and metabolic-related liver diseases, but the underlying mechanism remains unknown. ? 2014 American Association for Cancer Research.
SDGs
Other Subjects
adiponectin; alanine aminotransferase; aspartate aminotransferase; cholesterol; hepatitis B surface antigen; leptin; nicotinamide phosphoribosyltransferase; triacylglycerol; virus DNA; adipocytokine; adiponectin; cytokine; leptin; nicotinamide phosphoribosyltransferase; nicotinamide phosphoribosyltransferase, human; adult; aged; alanine aminotransferase blood level; alcohol consumption; article; aspartate aminotransferase blood level; betel nut; cancer risk; case control study; cholesterol blood level; controlled study; diabetes mellitus; disease association; fatty liver; female; genotype; hepatitis B; Hepatitis B virus; human; human tissue; hypertension; liver cell carcinoma; liver cirrhosis; major clinical study; male; priority journal; prospective study; protein blood level; smoking; Taiwan; triacylglycerol blood level; virus load; waist circumference; waist hip ratio; blood; Carcinoma, Hepatocellular; complication; hepatitis B; incidence; Liver Neoplasms; middle aged; risk factor; virology; Adipokines; Adiponectin; Adult; Aged; Carcinoma, Hepatocellular; Case-Control Studies; Cytokines; Female; Hepatitis B, Chronic; Humans; Incidence; Leptin; Liver Neoplasms; Male; Middle Aged; Nicotinamide Phosphoribosyltransferase; Risk Factors
Publisher
American Association for Cancer Research Inc.
Type
journal article