Characterization of plaques using 18F-FDG PET/CT in patients with carotid atherosclerosis and correlation with matrix metalloproteinase-1
Journal
Journal of Nuclear Medicine
Journal Volume
48
Journal Issue
2
Pages
227-233
Date Issued
2007
Author(s)
KAI-YUAN TZEN
Huang P.-J.
Abstract
High tissue matrix metalloproteinase (MMP) activity has been associated with advanced atherosclerosis and plaque rupture. 18F-FDG uptake has been reported to detect inflammation. This investigation examined the vascular 18F-FDG uptake by PET/CT and its correlation with circulating MMP-1 levels. Methods: We examined 25 consecutive patientswith significant carotid stenosis and 22 healthy control subjects using 18F-FDG PET/CT. The leukocyte counts, C-reactive protein (CRP), and MMP-1 were measured. Results: 18F-FDG arterial uptake, as well as calcifications, was significantly higher in extensive distributions in patients with established carotid stenosis. However, their distribution was not consistently overlapping. The values of circulating MMP-1 and leukocyte counts were significantly higher in patients with carotid stenosis (all P < 0.05). In addition, subjects with higher 18F-FDG uptake (maximum SUV > 2.0) in target lesions had higher baseline and poststenting MMP-1 levels (all P < 0.05). Conclusion: We provide a link between 18F-FDG uptake and circulating MMP-1. 18F-FDG PET/CT could be used as an adjunct to the clinical management of high-risk atherosclerosis and an in vivo tool to study plaque biology. Copyright ? 2007 by the Society of Nuclear Medicine, Inc.
SDGs
Other Subjects
C reactive protein; fluorodeoxyglucose f 18; interstitial collagenase; biological marker; diagnostic agent; fluorodeoxyglucose f 18; interstitial collagenase; radiopharmaceutical agent; adult; aged; artery calcification; article; atherosclerosis; atherosclerotic plaque; carotid artery obstruction; clinical article; computer assisted tomography; controlled study; drug uptake; enzyme activity; female; high risk patient; human; in vivo study; inflammation; leukocyte count; male; positron emission tomography; priority journal; stent; calcinosis; carotid artery disease; carotid artery obstruction; computer assisted tomography; digital subtraction angiography; enzymology; image processing; radiography; scintiscanning; thoracic aorta; Aged; Angiography, Digital Subtraction; Aorta, Thoracic; Biological Markers; Calcinosis; Carotid Artery Diseases; Carotid Stenosis; Female; Fluorodeoxyglucose F18; Humans; Image Processing, Computer-Assisted; Leukocyte Count; Male; Matrix Metalloproteinase 1; Radiopharmaceuticals; Tomography, X-Ray Computed
Type
journal article