https://scholars.lib.ntu.edu.tw/handle/123456789/567677
標題: | Plasma adiponectin levels and metabolic factors in nondiabetic adolescents | 作者: | KUO-CHIN HUANG BEE-HORNG LUE RUOH-FANG YEN Shen C.G. Ho S.-R. TONG-YUAN TAI WEI-SHIUNG YANG |
公開日期: | 2004 | 出版社: | North American Assoc. for the Study of Obesity | 卷: | 12 | 期: | 1 | 起(迄)頁: | 119-124 | 來源出版物: | Obesity Research | 摘要: | Objectives: The relationship of plasma adiponectin levels with various anthropometric and metabolic factors has been surveyed extensively in adults. However, how plasma adiponectin levels are related to various anthropometric indices and cardiovascular risk factors in adolescents is not as vigorously studied. In this study, we investigated this among healthy nondiabetic adolescents. Research Methods and Procedures: Two hundred thirty nondiabetic subjects (125 boys and 105 girls, ?10 to 19 years old) were included. The plasma adiponectin, fasting plasma glucose, insulin, lipids and anthropometric indices including body height, weight, waist circumference, and hip circumference were examined. Body fat mass (FM) and percentage were obtained from DXA scan. The homeostasis model assessment was applied to estimate the degree of insulin resistance. Results: The plasma adiponectin levels were significantly higher in girls (30.79 ± 14.48 μg/mL) than boys (22.87 ± 11.41 μg/mL). The plasma adiponectin levels were negatively related to BMI, FM, FM percentage, waist circumference, waist-to-hip ratio, insulin resistance, plasma insulin, triglycerides, and uric acid levels, but positively with high-density lipoprotein cholesterol (HDL-C) with the adjustment for age and gender. Using different multivariate linear regression models, only age and HDL-C were consistently related to the plasma adiponectin levels after adjustment for the other variables. Discussion: The relationship between plasma adiponectin and various anthropometric indices and metabolic factors, especially HDL-C, previously reported in adults was present in the healthy nondiabetic adolescents. Whether variation of plasma adiponectin levels in healthy nondiabetic adolescents may influence their future coronary artery disease risk warrants further investigation. Copyright ? 2004 NAASO. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-2342537854&doi=10.1038%2foby.2004.16&partnerID=40&md5=60e83357c0896ba4654caf1ccf5f422e https://scholars.lib.ntu.edu.tw/handle/123456789/567677 |
ISSN: | 1071-7323 | DOI: | 10.1038/oby.2004.16 | SDG/關鍵字: | adiponectin; high density lipoprotein cholesterol; insulin; lipid; protein; signal peptide; adolescent; adult; article; blood; body composition; body constitution; body height; body mass; body weight; child; diet restriction; female; glucose blood level; human; male; reference value; sexual development; statistical model; Adiponectin; Adolescent; Adult; Blood Glucose; Body Composition; Body Constitution; Body Height; Body Mass Index; Body Weight; Child; Cholesterol, HDL; Fasting; Female; Humans; Insulin; Intercellular Signaling Peptides and Proteins; Linear Models; Lipids; Male; Proteins; Reference Values; Sex Characteristics |
顯示於: | 醫學系 |
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