https://scholars.lib.ntu.edu.tw/handle/123456789/567771
標題: | Toll-like receptor 1 N248S polymorphism affects T helper 1 cytokine production and is associated with serum immunoglobulin E levels in Taiwanese allergic patients | 作者: | Yang C.-A. BOR-LUEN CHIANG |
關鍵字: | Allergy; Genetic polymorphism; Immunoglobulin E; Toll-like receptor | 公開日期: | 2017 | 出版社: | Elsevier Ltd | 卷: | 50 | 期: | 1 | 起(迄)頁: | 112-117 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background/purpose This study was carried out to investigate whether toll-like receptor-1 (TLR1) rs4833095 (N248S) variant, common in the Taiwanese population, contributes to pathogenesis of allergy. Methods TLR2/1 ligand Pam3CSK4-stimulated cytokine production in peripheral blood mononuclear cells and monocyte-derived dendritic cells of different genotypes were measured via enzyme-linked immunosorbent assay. Ninety-three Taiwanese allergic patients (with asthma, allergic rhinitis, or atopic dermatitis) and 76 controls were recruited for genotyping. Serum immunoglobulin E (IgE) levels were evaluated in 60 allergic patients. Results The homozygous TLR1 C variant allele carrier had increased Pam3CSK4-induced tumor necrosis factor-α and interleukin-12 responses in peripheral blood mononuclear cells and monocyte-derived dendritic cells, respectively. Furthermore, although the C/C genotype was not associated with susceptibility to atopic diseases, it was correlated with lower total IgE levels in sera of allergic patients. Conclusion Our data suggest that the TLR1 N248S polymorphism might play a role in Th1/Th2 differentiation, and the determination of serum IgE levels. However, interactions with other genetic and environmental factors might be required to contribute to risk of allergic diseases in our population. ? 2015 |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84925865198&doi=10.1016%2fj.jmii.2015.01.004&partnerID=40&md5=ec225c0223d378987be857734f7696fa https://scholars.lib.ntu.edu.tw/handle/123456789/567771 |
ISSN: | 1684-1182 | DOI: | 10.1016/j.jmii.2015.01.004 | SDG/關鍵字: | immunoglobulin E; interleukin 12; toll like receptor 1; toll like receptor 2; tumor necrosis factor; cytokine; immunoglobulin E; toll like receptor 1; allergic asthma; allergic rhinitis; allergy; Article; atopic dermatitis; child; controlled study; cytokine production; dendritic cell; female; genetic association; genetic polymorphism; genetic variability; genotype; human; immune response; immunoglobulin blood level; immunopathogenesis; major clinical study; male; peripheral blood mononuclear cell; population genetics; retrospective study; Taiwanese; Th1 cell; adolescent; blood; chemistry; enzyme linked immunosorbent assay; genetic polymorphism; genetic predisposition; genetics; genotyping technique; hypersensitivity; immunology; missense mutation; pathology; preschool child; secretion (process); serum; Taiwan; Th1 cell; Adolescent; Child; Child, Preschool; Cytokines; Enzyme-Linked Immunosorbent Assay; Female; Genetic Predisposition to Disease; Genotyping Techniques; Humans; Hypersensitivity; Immunoglobulin E; Male; Mutation, Missense; Polymorphism, Genetic; Serum; Taiwan; Th1 Cells; Toll-Like Receptor 1 |
顯示於: | 醫學系 |
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