CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus
Journal
Journal of the Formosan Medical Association
Journal Volume
111
Journal Issue
9
Pages
465-470
Date Issued
2012
Author(s)
Suen J.-L.
Abstract
Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies. Recent studies have suggested a dysregulation of regulatory T-cells (Tregs), particularly CD4+CD25highFoxP3+ (forkhead box P3) Tregs, as one of the major factors conferring the risk for expression of human autoimmune diseases, including SLE. However, detailed studies of CD4+FoxP3+ T-cells in patients with SLE remain limited. We attempt here to integrate the current experimental evidence to delineate the role of CD4+CD25high and other subsets of CD4+FoxP3+ T-cells in human SLE. ? 2012.
Subjects
FoxP3; Regulatory T-cell; Systemic lupus erythematosus
SDGs
Other Subjects
transcription factor FOXP3; adaptive immunity; CD4+ CD25+ T lymphocyte; CD4+ T lymphocyte; cell function; cell therapy; human; immunotherapy; innate immunity; nonhuman; protein expression; regulatory T lymphocyte; review; systemic lupus erythematosus; Antigens, CD4; Forkhead Transcription Factors; Humans; Lupus Erythematosus, Systemic; T-Lymphocytes, Regulatory
Type
review