https://scholars.lib.ntu.edu.tw/handle/123456789/567844
標題: | CD4+FoxP3+ regulatory T-cells in human systemic lupus erythematosus | 作者: | Suen J.-L. BOR-LUEN CHIANG |
關鍵字: | FoxP3; Regulatory T-cell; Systemic lupus erythematosus | 公開日期: | 2012 | 卷: | 111 | 期: | 9 | 起(迄)頁: | 465-470 | 來源出版物: | Journal of the Formosan Medical Association | 摘要: | Systemic lupus erythematosus (SLE) is a systemic autoimmune disease characterized by a loss of immune tolerance to self antigens and by the persistent production of pathogenic autoantibodies. Recent studies have suggested a dysregulation of regulatory T-cells (Tregs), particularly CD4+CD25highFoxP3+ (forkhead box P3) Tregs, as one of the major factors conferring the risk for expression of human autoimmune diseases, including SLE. However, detailed studies of CD4+FoxP3+ T-cells in patients with SLE remain limited. We attempt here to integrate the current experimental evidence to delineate the role of CD4+CD25high and other subsets of CD4+FoxP3+ T-cells in human SLE. ? 2012. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-84867012608&doi=10.1016%2fj.jfma.2012.05.013&partnerID=40&md5=2ac855c74b71d19097b32df1e4ce0bed https://scholars.lib.ntu.edu.tw/handle/123456789/567844 |
ISSN: | 0929-6646 | DOI: | 10.1016/j.jfma.2012.05.013 | SDG/關鍵字: | transcription factor FOXP3; adaptive immunity; CD4+ CD25+ T lymphocyte; CD4+ T lymphocyte; cell function; cell therapy; human; immunotherapy; innate immunity; nonhuman; protein expression; regulatory T lymphocyte; review; systemic lupus erythematosus; Antigens, CD4; Forkhead Transcription Factors; Humans; Lupus Erythematosus, Systemic; T-Lymphocytes, Regulatory |
顯示於: | 醫學系 |
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