https://scholars.lib.ntu.edu.tw/handle/123456789/567954
標題: | Thrombopoietin and interleukin-6 levels in Henoch-Schönlein purpura | 作者: | Lin C.-Y. YAO-HSU YANG CHIEN-CHANG LEE Huang C.-L. LI-CHIEH WANG BOR-LUEN CHIANG |
公開日期: | 2006 | 卷: | 39 | 期: | 6 | 起(迄)頁: | 476-482 | 來源出版物: | Journal of Microbiology, Immunology and Infection | 摘要: | Background and Purpose: Depending on the severity of the illness, thrombocytosis is found in about 60% to 70% of patients with Henoch-Sch?nlein purpura (HSP). Whether thrombocytosis is the result of an inflammatory reaction mediated by thrombopoietin (TPO) or other inflammatory cytokines such as interleukin (IL)-6 remains unknown. Methods: Thirty two patients who met the diagnostic criteria for HSP were included. They were divided into two groups - HSP patients with thrombocytosis (n = 14) and those without thrombocytosis (n = 18) with a platelet count of 400,000/μL. Eight normal healthy controls were also included. TPO and IL-6 serum levels during the acute phase were measured by enzyme-linked immunosorbent assay. Results: Patients with platelet counts greater than 400,000/μL in the acute stage had significantly lower TPO levels than patients with platelet counts lower than 400,000/μL (310 ± 65.6 pg/mL vs 608 ± 97.8 pg/mL, p=0.013). However, HSP patients with or without thrombocytosis had similar TPO levels as the healthy controls (441 ± 176 pg/mL, p=0.89 and 0.29, respectively). IL-6 serum levels were significantly elevated in HSP patients during the acute stage of HSP (28.6 ± 61.7 pg/mL vs 3.16 ± 1.35 pg/mL, p=0.049). In patients with complications of glomerulonephritis or gastrointestinal hemorrhage (n = 12), IL-6 levels were significantly lower than in those without such complications (8.07 ± 3.79 pg/mL vs 40.9 ± 16.9 pg/mL, p=0.007). Conclusions: This study showed that thrombocytosis in HSP patients is a type of inflammatory reactive thrombocytosis, and that IL-6 may also play a role in the pathogenesis of HSP. ? 2006 Journal of Microbiology, Immunology and Infection. |
URI: | https://www.scopus.com/inward/record.uri?eid=2-s2.0-33847694008&partnerID=40&md5=f77a61f3df512f53bbb4ee8d40e551dc https://scholars.lib.ntu.edu.tw/handle/123456789/567954 |
ISSN: | 1684-1182 | SDG/關鍵字: | interleukin 6; thrombopoietin; interleukin 6; thrombopoietin; anaphylactoid purpura; article; child; clinical article; controlled study; disease severity; enzyme linked immunosorbent assay; female; gastrointestinal hemorrhage; glomerulonephritis; human; infant; inflammation; male; thrombocyte count; thrombocytosis; anaphylactoid purpura; blood; pathophysiology; preschool child; Taiwan; teaching hospital; thrombocytosis; Child; Child, Preschool; Female; Hospitals, Teaching; Humans; Infant; Interleukin-6; Male; Platelet Count; Purpura, Schoenlein-Henoch; Taiwan; Thrombocytosis; Thrombopoietin |
顯示於: | 醫學系 |
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